Effects of Exercise on the Level of Antibodies against Endogenous Bioregulators in the Serum of Athletes

详细

We measured the level of natural antibodies against serotonin, histamine, dopamine, glutamate, GABA, orphanin, β-endorphin, and angiotensin by ELISA in the serum of athletes. The study included 52 hockey players aged 18–24 years; we used step-by-step physical load testing on a Sheller bicycle ergometer. Significant differences in the level of antibodies against dophamine, orphanin, GABA, and glutamate were found after exercise when compared to the indicators at rest. Correlation coefficients were the following: r = 0.88 for serotonin antibodies, r = 0.82 for dopamine, r = 0.78 for orphanin, r = 0.80 for GABA, and r = 0.72 for glutamate, p < 0.05. A significant correlation was found between the changes in serotonin, glutamate, and GABA antibodies after exercise and biochemical parameters. The relationship between the level of antibodies against GABA and the glucose concentration was r = 0.38 at p = 0.047; the relationship between serotonin levels and iron concentration was r = –0.45, p = 0.015. The correlation coefficient of the increase in the content of creatinine phosphokinase (CРК) and the level of antibodies against glutamate was r = 0.50, p = 0.048. The data prove the diagnostic significance of immunological parameters concerning dophamine, orphanin, GABA, and glutamate for the estimation of adaptation and stability of the physical form of examined hockey players.