Associations of Alu I/D Polymorphism of the Angiotensin Converting Enzyme Gene and 4b/a Polymorphism of the Nitric Oxide Synthase Gene with Heart Rate Variability and Cardiovascular Hemodynamics in Rowers
- 作者: Melnikov A.1, Bobylev A.1, Kylosov A.2
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隶属关系:
- Yaroslavl State Pedagogical University n.a. K.D. Ushinsky
- Cherepovets State University
- 期: 卷 44, 编号 5 (2018)
- 页面: 605-607
- 栏目: Short Communications
- URL: https://journals.rcsi.science/0362-1197/article/view/177810
- DOI: https://doi.org/10.1134/S0362119718050080
- ID: 177810
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详细
We studied the influence of the ACEAluI/D and NOS3 4b/a polymorphisms on the heart rate variability (HRV) and cardiovascular hemodynamics (CVH, by cardiac rheography) in rowers, including Candidates for Master of Sports (CMS, n = 6) and athletes with no rank (AWR, n = 16). It has been found that the VO2max (р < 0.001) and HRV (all indexes, p < 0.05) in the supine and standing positions were higher in the CMS athletes than in AWR athletes. The frequency of the I allele of the ACE genein the CMS group (58%) did not differ from the mean population value (n = 855, 48.4%) but was higher than in the AWR group (13%, p = 0.035), which was associated with increased HF regardless of VO2max (p = 0.029). The frequencies of genotypes of NOS3 4b/a did not differ between groups, but the 4a allele was associated with an increased VLF%. Thus, elevated HRV in trained athletes may be caused by genetic factors, among which the I allele of the ACE gene may play an important role.
作者简介
A. Melnikov
Yaroslavl State Pedagogical University n.a. K.D. Ushinsky
编辑信件的主要联系方式.
Email: meln1974@yandex.ru
俄罗斯联邦, Yaroslavl
A. Bobylev
Yaroslavl State Pedagogical University n.a. K.D. Ushinsky
Email: meln1974@yandex.ru
俄罗斯联邦, Yaroslavl
A. Kylosov
Cherepovets State University
Email: meln1974@yandex.ru
俄罗斯联邦, Cherepovets