Gravisensitivity of endothelial cells: the role of cytoskeleton and adhesion molecules
- 作者: Rudimov E.1, Buravkova L.1
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隶属关系:
- Institute of Biomedical Problems
- 期: 卷 42, 编号 6 (2016)
- 页面: 687-693
- 栏目: Reviews
- URL: https://journals.rcsi.science/0362-1197/article/view/176835
- DOI: https://doi.org/10.1134/S0362119716060177
- ID: 176835
如何引用文章
详细
The review addresses the effect of microgravity on the endothelial cells, an important mechanosensory element of the cardiovascular system that is known to undergo functional changes in space flight. The chalanges that arise in performing space flight experiments are presented, as well as approaches used to simulate microgravity effects in vitro. The role of cytoskeletal elements as the putative gravity sensors in the cells is demonstrated. The changes in the expression of adhesion molecules that may underlie the mechanisms of gravity sensing by endothelial cells are described. The possible reasons for the discrepancies between the results obtained, such as the differences between the cell lines and experimental design, the variation in time of cultivation, and the specific spaceflight related factors, are analyzed.
作者简介
E. Rudimov
Institute of Biomedical Problems
Email: buravkova@imbp.ru
俄罗斯联邦, Moscow
L. Buravkova
Institute of Biomedical Problems
编辑信件的主要联系方式.
Email: buravkova@imbp.ru
俄罗斯联邦, Moscow