Concentration of Selected Osteotropic Growth Factors and Markers of Osteogenesis in the Blood of Somatically Healthy Children and Adults
- Authors: Vykhovanets E.P.1, Luneva S.N.1, Nakoskina N.V.1
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Affiliations:
- Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation
- Issue: Vol 45, No 1 (2019)
- Pages: 83-89
- Section: Article
- URL: https://journals.rcsi.science/0362-1197/article/view/178090
- DOI: https://doi.org/10.1134/S0362119718060130
- ID: 178090
Cite item
Abstract
Currently, many studies are conducted on the concentration of growth factors and markers of osteogenesis in various human pathologies. However, there are still no data on the normal levels of growth factors and their receptors in the blood serum. Therefore, the purpose of this study was to determine the serum concentrations of some osteotropic growth factors and osteogenesis markers in somatically healthy children and adults of different age periods. The growth factors were assayed by means of a Thermofisher set of equipment (United States). Analysis was performed as recommended in manuals to the kits purchased from eBioscience (TGF-β1.2; VEGF-A; VEGF-R2, R3), Immunodiagnostic Systems (IGF-1; osteocalcin; 1,25-ergocalciferol; CrossLaps), Invitrogen (VEGF), RayBiotech (FGF-basic, acidic; TGF-α; SCF; SCF sR) (United States); Mediagnost (IGF-2), QULDEL (PYD), and Enzo (DKK-1) (Germany). There were no significant differences in the following serum concentrations between gender and age groups: PYD, 1,25-ergocalciferol, TGF-β1, FGF-basic, and IGF-2. Age-related differences were observed in the following factors: CrossLaps, osteocalcin, VEGF-R3, VEGF-A, and IGF-1. Sex-related differences were observed in the VEGF-R2 and VEGF. For the other growth factors and receptors, both sex- and age-related differences were observed.
About the authors
E. P. Vykhovanets
Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation
Author for correspondence.
Email: Vykhovanets.eva@mail.ru
Russian Federation, Kurgan
S. N. Luneva
Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation
Email: Vykhovanets.eva@mail.ru
Russian Federation, Kurgan
N. V. Nakoskina
Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Ministry of Health of the Russian Federation
Email: Vykhovanets.eva@mail.ru
Russian Federation, Kurgan