Efficacy of Inhibitory Control in Antisaccade Task and the Polymorphisms of DRD2 Dopamine Receptor Gene in Schizophrenic Patients

Abstract

The purpose of this pilot study was to investigate the association of five polymorphic loci of the DRD2 gene (rs1799732, rs1800497, rs6277, rs6275, and rs2242592) with antisaccade task performance in male cohorts of schizophrenic patients (n = 33) and healthy subjects (n = 30). The antisaccade error rate was analyzed as related to prefrontal inhibitory control. In patients, the increased percent of errors was associated with minor alleles of polymorphisms rs6277 (C), rs6275 (T), and rs2242592 (G), which are supposedly related to the risk of schizophrenia. At the same time, it was found that a decreased error rate in healthy subjects is associated with the C/C variant of rs6277; no association was observed between polymorphisms rs6275 and rs2242592 and task performance.