Внеклеточный матрикс как фактор регуляции физиологического микроокружения клетки
- Авторы: Андреева Е.Р.1, Матвеева Д.К.1, Жидкова О.В.1, Буравкова Л.Б.1
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Учреждения:
- ГНЦ РФ Институт медико-биологических проблем РАН
- Выпуск: Том 55, № 1 (2024)
- Страницы: 16–30
- Раздел: Статьи
- URL: https://journals.rcsi.science/0301-1798/article/view/255705
- DOI: https://doi.org/10.31857/S0301179824010033
- ID: 255705
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Аннотация
Внеклеточный матрикс (ВКM) представляет собой динамическую трехмерную сеть макромолекул, которая обеспечивает структурную поддержку клеток и тканей. За последние десятилетия накоплен значительный массив данных, показывающих, что ВКM играет также ключевую регуляторную роль. Структурные компоненты ВКМ (белки, гликопротеины, протеогликаны, гликозаминогликаны), комплекс ремоделирующих молекул (ферменты и их ингибиторы), депонируемые / высвобождаемые биологически активные медиаторы образуют единую функциональную систему, которая обеспечивает физиологический гомеостаз в тканях. ВКM может постоянно адаптироваться под действием механических, биохимических, физических сигналов, обеспечивая возможность конфигурирования различных тканей в соответствии с требованиями к их функциям. В обзоре кратко представлены современные данные о структурных компонентах ВКМ. Специальное внимание уделено аспектам, связанным с депонирующей функцией, а также биологически активным продуктам, образующимся в результате физиологического ремоделирования ВКМ. Обсуждена роль важнейшего физического фактора микроокружения – тканевого уровня кислорода в физиологию ВКМ клеток стромального дифферона.
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Об авторах
Е. Р. Андреева
ГНЦ РФ Институт медико-биологических проблем РАН
Автор, ответственный за переписку.
Email: elena.rjnrepz@yandex.ru
Россия, 123007, Москва
Д. К. Матвеева
ГНЦ РФ Институт медико-биологических проблем РАН
Email: matveeva.dajana@yandex.ru
Россия, 123007, Москва
О. В. Жидкова
ГНЦ РФ Институт медико-биологических проблем РАН
Email: olgavzhidkova@gmail.com
Россия, 123007, Москва
Л. Б. Буравкова
ГНЦ РФ Институт медико-биологических проблем РАН
Email: buravkova@imbp.ru
Россия, 123007, Москва
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