Фармакологические эффекты фактора роста фибробластов 21 (FGF21) на углеводно-жировой обмен: зависимость от пола
- Авторы: Бажан Н.М.1, Макарова Е.Н.1
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Учреждения:
- Федеральное государственное бюджетное учреждение науки Институт цитологии и генетики СО РАН
- Выпуск: Том 54, № 4 (2023)
- Страницы: 93-104
- Раздел: Статьи
- URL: https://journals.rcsi.science/0301-1798/article/view/232640
- DOI: https://doi.org/10.31857/S0301179823040033
- EDN: https://elibrary.ru/DYAYCL
- ID: 232640
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Аннотация
Фактор роста фибробластов (FGF21) является гормоном печени, который способствует адаптации организма к различным ситауциям, вызывающим напряжение систем метаболизма. В обзоре рассмотрены некоторые нерешенные вопросы, касающиеся физиологического действия этого уникального метаболического регулятора, суммированы основные знания о фармакологических свойствах FGF21 и освещены половые различия в их проявлении при коррекции ожирения. Обобщены результаты, показывающие, что эффективность использования FGF21 для терапии ожирения зависит от этиологии ожирения и пола. Подчеркивается необходимость исследования механизмов возникновения половых различий действия FGF21 для его успешного использования при лечении ожирения у особей мужского и женского пола.
Ключевые слова
Об авторах
Н. М. Бажан
Федеральное государственное бюджетное учреждение науки Институт цитологии и генетики СО РАН
Автор, ответственный за переписку.
Email: bazhan-nm@yandex.ru
Россия, 630090, Новосибирск
Е. Н. Макарова
Федеральное государственное бюджетное учреждение науки Институт цитологии и генетики СО РАН
Автор, ответственный за переписку.
Email: enmakarjva@gmail.com
Россия, 630090, Новосибирск
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