Association of COL1A1, ESR1, and VDR gene polymorphisms with the risk of pelvic floor dysfunction in postpartum women
- 作者: Mikhelson A.1, Lukianova K.1, Lazukina M.1, Varlamova A.1, Tretyakova T.1, Varaksin A.2, Konstantinova E.2, Maslakova T.2
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隶属关系:
- Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of the Russian Federation
- Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences
- 期: 编号 5 (2024)
- 页面: 82-91
- 栏目: Original Articles
- URL: https://journals.rcsi.science/0300-9092/article/view/258711
- DOI: https://doi.org/10.18565/aig.2024.18
- ID: 258711
如何引用文章
详细
Objective: To investigate the influence of collagen type 1 gene polymorphisms, estrogen receptors, and vitamin D receptors on early development of pelvic floor dysfunction in postpartum women.
Materials and methods: This prospective cohort study enrolled 120 women who delivered naturally. The patients were divided into two groups. Group 1 (study group) consisted of 67 women who developed pelvic floor dysfunction, such as pelvic organ prolapse and urinary incontinence, six months postpartum. Group 2 (control group) included 53 women who did not develop pelvic floor dysfunction within six months postpartum. Molecular genetic typing and determination of COL1A1 gene polymorphisms -1997 C>A and 1546 G>T, ESR1 gene -397 T>C and -351 G>A, and VDR gene 283 A>G and 2 A>G were conducted for all women.
Results: Among patients who developed pelvic floor dysfunction after delivery, carriage of the minor allele G of the ESR1:A-351G polymorphic marker was more common than that in healthy women, where the predominant allele was ESR1:-351 A. The presence of the variant allele -397 C of the ESR1 gene in the homozygous or heterozygous state of the genotype is associated with an increased risk of developing this pathology.
Conclusion: The polymorphism of the ESR1 gene at loci -351 A>G and -397 T>C is associated with the development of pelvic organ prolapse and urinary incontinence 6 months after natural childbirth. No association was found between COL1A1 and VDR gene polymorphisms and the early development of pelvic floor dysfunction after childbirth.
作者简介
Anna Mikhelson
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: ann_tolmik@mail.ru
ORCID iD: 0000-0003-1709-6187
Dr. Med. Sci., Associate Professor, Head of the Scientific Department for the Preservation of Reproductive Function, Head of the Gynecological Department
俄罗斯联邦, YekaterinburgKsenia Lukianova
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of the Russian Federation
Email: k.d.lukianova@mail.ru
Obstetrician-Gynecologist
俄罗斯联邦, YekaterinburgMaria Lazukina
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of the Russian Federation
Email: masha_balueva@mail.ru
ORCID iD: 0000-0002-0525-0856
PhD, Researcher, Obstetrician-Gynecologist
俄罗斯联邦, YekaterinburgAnastasia Varlamova
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of the Russian Federation
Email: ann_tolmik@mail.ru
ORCID iD: 0009-0008-7703-4248
PhD Student, Obstetrician-Gynecologist
俄罗斯联邦, YekaterinburgTatyana Tretyakova
Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of the Russian Federation
Email: ann_tolmik@mail.ru
ORCID iD: 0000-0002-5715-7514
PhD, Senior Researcher at the Genetic Research Group, Biochemical Research Methods Division, Laboratory Geneticist
俄罗斯联邦, YekaterinburgAnatoly Varaksin
Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences
Email: varaksin@ecko.uran.ru
ORCID iD: 0000-0003-2689-3006
Dr. Sci. (Physics and Mathematics), Professor, Chief Researcher at the Laboratory of Mathematical Modeling in Ecology and Medicine
俄罗斯联邦, YekaterinburgEkaterina Konstantinova
Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences
Email: ann_tolmik@mail.ru
ORCID iD: 0000-0002-2260-744X
PhD, Senior Researcher, Head of the Laboratory of Mathematical Modeling in Ecology and Medicine
俄罗斯联邦, YekaterinburgTatyana Maslakova
Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences
Email: ann_tolmik@mail.ru
ORCID iD: 0000-0001-6642-9027
PhD, Researcher at the Laboratory of Mathematical Modeling in Ecology and Medicine, Institute of Industrial Ecology
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