Portal vein thrombosis while taking a combined oral contraceptive after experienced coronavirus infection
- 作者: Shklyaev A.1, Fatkhieva A.1, Bessonov A.2, Meleshkina M.2, Zykov S.2
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隶属关系:
- Izhevsk State Medical Academy, Ministry of Health of Russia
- First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
- 期: 编号 2 (2023)
- 页面: 165-170
- 栏目: Clinical Notes
- URL: https://journals.rcsi.science/0300-9092/article/view/258679
- DOI: https://doi.org/10.18565/aig.2023.5
- ID: 258679
如何引用文章
详细
Background: Contraceptives are an important component of women’s reproductive health care, as they not only reduce the number of unwanted pregnancies, but also improve reproductive function. However, oral contraceptives are known to increase the risk of venous thromboembolism. This risk is increased by infection with the COVID-19 virus that predisposes patients to both venous and arterial thrombosis as a result of excessive inflammation, platelet activation, aggravated endothelial dysfunction, and congestive events. If these patients have hereditary thrombophilia, the risk of venous thromboembolism becomes fatal.
Case report: The paper describes a clinical case of a patient with total portal vein thrombosis, who have been taking oral contraceptives for a long time and recovering from the novel coronavirus infection. Studying the blood coagulation system and folate cycle genes, by using PCR, has revealed a gene mutation in the plasminogen activator inhibitor (serpine). The authors demonstrate the data of spiral computed tomography of the abdominal organs, as well as changes in laboratory parameters.
Conclusion: A balanced approach is required when prescribing combined oral contraceptives during the COVID-19 pandemic, especially in women with prothrombotic mutations.
作者简介
Alexey Shklyaev
Izhevsk State Medical Academy, Ministry of Health of Russia
Email: shklyaevaleksey@gmail.com
ORCID iD: 0000-0003-4479-508X
Dr. Med. Sci., Professor, Professor at the Department of Faculty Therapy with courses of endocrinology and hematology
俄罗斯联邦, IzhevskAlina Fatkhieva
Izhevsk State Medical Academy, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: alifathi98@mail.ru
student
俄罗斯联邦, IzhevskAlexey Bessonov
First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
Email: besson_alex@mail.ru
PhD, Head of the Gastroenterology Department
俄罗斯联邦, IzhevskMaria Meleshkina
First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
Email: alifathi98@mail.ru
gastroenterologist
俄罗斯联邦, IzhevskSergey Zykov
First Republican Clinical Hospital, Ministry of Health of the Udmurt Republic
Email: sergeyzykov1977@gmail.com
radiologist
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