Excess adipose tissue and chronic subclinical inflammation in patients with polycystic ovary syndrome
- Авторлар: Kirillova E.1, Krechetova L.1, Vtorushina V.1, Ivanets T.1, Chernukha G.1
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Мекемелер:
- Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
- Шығарылым: № 4 (2023)
- Беттер: 111-119
- Бөлім: Original Articles
- URL: https://journals.rcsi.science/0300-9092/article/view/258559
- DOI: https://doi.org/10.18565/aig.2023.56
- ID: 258559
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Objective: To analyze the serum levels of proinflammatory markers in patients with polycystic ovary syndrome (PCOS) and assess their association with body composition and metabolic parameters.
Materials and methods: This single-center cross-sectional study included 148 women with PCOS (mean age 25.1 (5.5) years). Of these, 118 had PCOS (mean age 25.1 (5.5) years), 14 were overweight and obese without PCOS (mean age 26.1 (7.4) years) and 16 were somatically healthy women (mean age 25.3 (5.1) years). All participants underwent comprehensive clinical, laboratory, and instrumental examination.
Results: Patients with PCOS had significantly higher levels of IL-6, TNF-α, and CRP than those in the control group; however, there were no statistically significant differences in the levels of IL-1, leptin, and adiponectin. PCOS patients had signs of chronic subclinical inflammation in the form of elevated IL-6 and CRP levels in 39% and 37% of the cases, respectively. Hidden obesity was diagnosed in 65.0% of PCOS patients with a normal BMI, manifesting as excess visceral adipose tissue in 46.2% of cases. This group was seven times more likely to have elevated CRP levels and nearly four times more likely to be insulin resistant than patients with normal total body fat percentage.
Conclusion: It is appropriate to recommend adipose tissue densitometry and assessment of levels of proinflammatory markers to identify risk groups for pregnancy complications, cardiovascular disease, and type 2 diabetes mellitus in patients with PCOS with normal BMI and for further correction of modifiable risk factors by lifestyle changes, drug therapy, and pre-pregnancy care.
Толық мәтін
##article.viewOnOriginalSite##Авторлар туралы
Ekaterina Kirillova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: emiroshina.md@gmail.com
ORCID iD: 0000-0002-3723-5052
Junior Reseasrcher at the Department of Gynecological Endocrinology
Ресей, MoscowLyubov Krechetova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: k_l_v_@mail.ru
ORCID iD: 0000-0001-5023-3476
Dr. Med. Sci., Head of the Laboratory of Clinical Imunology
Ресей, MoscowValentina Vtorushina
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: v_vtorushina@oparina4.ru
PhD, Immunologist at the Laboratory of Clinical Immunology
Ресей, MoscowTatyana Ivanets
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: t_ivanets@oparina4.ru
ORCID iD: 0000-0002-7990-0276
Dr. Med. Sci., Head of the Clinical Diagnostic Laboratory
Ресей, MoscowGalina Chernukha
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation
Email: c-galina1@yandex.ru
ORCID iD: 0000-0002-9065-5689
Dr. Med. Sci., Professor, Chief Researcher, Department of Gynecological Endocrinology
Ресей, MoscowӘдебиет тізімі
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