Experimental modeling of mandibular defect and analysis of the functional efficiency of the jaw exoskeleton
- Authors: Loktionova M.V.1, Gabbasova I.V.2, Sletova V.A.2, Magomedova H.M.3, Uzdenov E.M.4, Zakharyan V.S.5, Sletov A.A.2,6, Admakin O.I.1
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
- Stavropol State Medical University, Ministry of Health of Russia
- Dagestan State Medical University, Ministry of Health of Russia
- Karachay-Cherkessia Medical Academy, Ministry of Health of Russia
- Kuban State Medical University, Ministry of Health of Russia
- Stavropol Territory Clinical Hospital
- Issue: Vol 34, No 2 (2023)
- Pages: 59-62
- Section: From Practice
- URL: https://journals.rcsi.science/0236-3054/article/view/143052
- DOI: https://doi.org/10.29296/25877305-2023-02-14
- ID: 143052
Cite item
Abstract
Modeling of jaw bone defects after bisphosphonate administration is presently an urgent task of oral surgery. Methods for virtual modeling of pathological processes and ways for their elimination are becoming increasingly popular in experimental studies. However, biomedical research with experimental animals, which is strictly regulated by law, does not lose its relevance. The choice of a model for our study has been based on the assumption that bisphosphonate-associated osteonecrosis and jaw defect in experimental animals are identical to human clinical presentations. In addition, this study considers the development of devices for correcting biomechanical problems and positioning the jaw bone fragments. Simulated subtotal mandibular defects are accompanied by restricted mouth opening, malnutrition and, as a result, inhibited habitual functional activity in the experimental animals. This has served as a guide for incorporating the simultaneous fixation of fragments with a multifunctional device, such as with the mandibular exoskeleton, into the protocol of surgical intervention. Positive changes in the early postoperative period have been characterized by restoration of the biomechanical balance of the dentition. The findings provide evidence that it is necessary to modernize the device and to test the exoskeleton in patients with subtotal mandibular defects.
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##article.viewOnOriginalSite##About the authors
M. V. Loktionova
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Author for correspondence.
Email: Marinavrach@mail.ru
ORCID iD: 0000-0003-3555-2035
Candidate of Medical Sciences
Russian Federation, MoscowI. V. Gabbasova
Stavropol State Medical University, Ministry of Health of Russia
Email: Marinavrach@mail.ru
ORCID iD: 0000-0003-3850-4274
Russian Federation, Stavropol
V. A. Sletova
Stavropol State Medical University, Ministry of Health of Russia
Email: Marinavrach@mail.ru
Russian Federation, Stavropol
H. M. Magomedova
Dagestan State Medical University, Ministry of Health of Russia
Email: Marinavrach@mail.ru
Russian Federation, Makhachkala
E. M. Uzdenov
Karachay-Cherkessia Medical Academy, Ministry of Health of Russia
Email: Marinavrach@mail.ru
Russian Federation, Cherkessk
V. S. Zakharyan
Kuban State Medical University, Ministry of Health of Russia
Email: Marinavrach@mail.ru
Russian Federation, Krasnodar
A. A. Sletov
Stavropol State Medical University, Ministry of Health of Russia; Stavropol Territory Clinical Hospital
Email: Marinavrach@mail.ru
ORCID iD: 0000-0001-5183-9330
Doctor of Medical Sciences, Professor
Russian Federation, Stavropol; StavropolO. I. Admakin
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: Marinavrach@mail.ru
ORCID iD: 0000-0002-5626-2961
Doctor of Medical Sciences, Professor
Russian Federation, MoscowReferences
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