Membrane and Cell BiologyMembrane and Cell BiologyБиологические мембраны0233-47553034-5219The Russian Academy of Sciences36223610.7868/S3034521925060017ОБЗОРЫResearch ArticleThe Role of Cx43 in the Survival and Death of Neurons and Glial Cells in Injuries of the Central and Peripheral Nervous SystemРОЛЬ Сх43 В ВЫЖИВАНИИ И ГИБЕЛИ НЕЙРОНОВ И ГЛИАЛЬНЫХ КЛЕТОК ПРИ ТРАВМАХ ЦЕНТРАЛЬНОЙ И ПЕРИФЕРИЧЕСКОЙ НЕРВНОЙ СИСТЕМЫNwosuCh. D.НвосуЧ. Д.chizaramwosu4@gmail.comKirichenkoE. Yu.КириченкоЕ. Ю.-LogvinovA. K.ЛогвиновА. К.-RodkinS. V.РодькинС. В.-Research Laboratory "Medical Digital Imaging Based on a Base Model"Донской государственный технический университетAcademy of Biology and Biotechnology, Southern Federal UniversityАкадемия биологии и биотехнологии, Южный федеральный университет15122025426VOL 42, NO6 (2025)ТОМ 42, №6 (2025)25122025Copyright ©; 2025, Russian Academy of SciencesCopyright ©; 2025, Российская академия наук2025Russian Academy of SciencesРоссийская академия наукhttps://journals.rcsi.science/0233-4755/article/view/362236

Connexin 43 (Cx43), a key protein of gap-junctional channels, plays a dual role in regulating the survival and death of neurons and glial cells during injuries to the central (CNS) and peripheral nervous systems (PNS). It supports neuroprotection by maintaining cellular homeostasis but can exacerbate secondary damage by promoting inflammation and apoptosis. This review examines in detail the role of Cx43 in these processes, emphasizing its ambivalent impact, which depends on cell type, injury phase, and molecular microenvironment. Additionally, mechanisms of intercellular communication and prospects for therapeutic modulation of Cx43 to optimize rehabilitation after neurotransmitter are discussed.

Коннексин 43 (Сх43) — ключевой белок шелевых контактов, которые играют двойственную роль в регуляции выживания и гибели нейронов и глиальных клеток при травмах центральной (ЦНС) и периферической нервной системы (ПНС). Он способствует нейропротекции, поддерживая клеточный гомеостаз, но может усиливать вторичные повреждения, провоцируя воспаление и апоптоз. В данном обзоре детально рассмотрена роль Сх43 в этих процессах с акцентом на его амбивалентное влияние, зависящее от типа клеток, фазы травмы и молекулярного микроокружения. Также обсуждаются механизмы межклеточной коммуникации и перспективы терапевтической модуляции Сх43 для оптимизации реабилитации после нейротравм.

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