The Role of Asprosin in the Regulation and Mechanisms of Oxygen Transport in the Blood and the Gas Transmitter System in Men with Different Body Mass Index

V. V. Zinchuk; Зинчук В. В.; Al-Jebur Jaafar Shati Owaid; Джаафар Шати Оваид Аль-Джебур; N. V. Glutkina; Глуткина Н. В.

doi:10.31857/S013116462260077X

The Role of Asprosin in the Regulation and Mechanisms of Oxygen Transport in the Blood and the Gas Transmitter System in Men with Different Body Mass Index

作者: Zinchuk V.¹, Jaafar Shati Owaid A.², Glutkina N.¹
隶属关系:
1. Grodno State Medical University
2. State University of Grodno Yanka Kupala
期: 卷 49, 编号 4 (2023)
页面: 101-107
栏目: Articles
URL: https://journals.rcsi.science/0131-1646/article/view/139850
DOI: https://doi.org/10.31857/S013116462260077X
EDN: https://elibrary.ru/MKQXNE
ID: 139850

如何引用文章

全文:

开放存取

##reader.subscriptionAccessGranted##
受限制的访问

订阅存取

详细
作者简介
参考
补充文件
统计

详细

The purpose of this study the role of asprosin in the regulation and mechanisms of oxygen transport in the blood and the gas transmitter system in men with different body mass index. The indicators of lipid and carbohydrate metabolism, as well as the oxygen transport function of the blood and the concentration of gas-transmitters nitrogen monoxide and hydrogen sulfide in it, were determined. A higher concentration of asprosin was found in individuals with an increased body mass index and grade I obesity. With an increased content of asprosin, there is a decrease in the main indicators of blood oxygenation and an increase in the affinity of hemoglobin for oxygen. An increase in the concentration of nitrogen monoxide and a decrease in hydrogen sulfide were revealed at a high content of asprosin, which may be important for the formation of the mechanisms of oxygen transport in the blood.

关键词

asprosin, hemoglobin affinity for oxygen, gas transmitter, nitrogen monoxide, hydrogen sulfide, blood.

参考

Рагино Ю.И., Щербакова Л.В., Облаухова В.И. др. Адипокины крови у молодых людей с ранней ишемической болезнью сердца на фоне абдоминального ожирения // Кардиология. 2021. Т. 6. № 4. С. 32. Ragino Yu.I., Shcherbakova L.V., Oblaukhova V.I. et al. [Blood adipokins in young people with early ischemic heart disease on the background of abdominal obesity] // Kardiologiia. 2021. V. 6. № 4. P. 32.
Romere C., Duerrschmid C., Bournat J. et al. Asprosin, a fasting-induced glucogenic protein hormone // Cell. 2016. V. 165. № 3. P. 566.
Yuan M., Li W., Zhu Y. et al. Asprosin: A Novel Player in Metabolic Diseases // Front. Endocrinol. 2020. V. 11. P. 64.
Seyhanli E.S., Koyuncu I., Yasak I.H. et al. Asprosin and Oxidative Stress Level in COVID-19 Patients // Clin. Lab. 2022. V. 68. https://doi.org/10.7754/clin.lab.2021.210423
Zinchuk V., Zhadko D. Association of endothelial nitric oxide synthase gene G894T polymorphism with blood oxygen transport // Nitric Oxide. 2019. V. 84. P. 45.
Зинчук В.В. Кислородтранспортная функция крови и газотрансмиттер сероводород // Успехи физиологических наук. 2021. Т. 52. № 3. С. 41. Zinchuk V.V. [Oxygen transport functions of blood and hydrogen sulfide gazotransmitter] // Progress in Physiological Science. 2021. V. 52. № 3. P. 41.
Куркин Д.В., Абросимова Е.Е., Бакулин Д.А. и др. Роль NO-ергической системы в регуляции углеводного обмена и развитии сахарного диабета // Успехи физиологических наук. 2022. Т. 53. № 1. С. 88. Kurkin D.V., Abrosimova E.E., Bakulin D.A. et al. [The role of the NO-ergic system in the regulation of carbohydrate metabolism and the development of diabetes mellitus] // Progress in Physiological Science. 2022. V. 53. № 1. P. 88.
Кузнецова Л.А. Метаболический синдром: влияние адипокинов на L-аргинин-NO-синтаза-NO сигнальный путь // Acta Biomedica Scientifica. 2021. Т. 6. № 2. С. 22. Kuznetsova L.A. Metabolic syndrome: the influence of adipokines on the L-arginine-NO synthase-nitric oxide signaling pathway // Acta Biomedica Scientifica. 2021. V. 6. № 2. P. 22.
Krakauer N.Y., Krakauer J.C. A new body shape index predicts mortality hazard independently of body mass index // PLoS One. 2012. V. 7. № 7. P. e39504.
Severinghaus J.W. Blood gas calculator // J. Appl. Physiol. 1966. V. 21. № 5. P. 1108.
Bryan N.S., Grisham M.B. Methods to detect nitric oxide and its metabolites in biological samples // Free Radic. Biol. Med. 2007. V. 43. № 5. P. 645.
Norris E.J., Culberson C.R., Narasimhan S., Clemens M.G. The Liver as a Central Regulator of Hydrogen Sulfide // Shock. 2011. V. 36. № 3. P. 242.
Голубева М.Г. Стрессогенные нарушения эритроцитов и их коррекция с помощью регуляторных пептидов // Успехи физиологических наук. 2018. Т. 49. № 1. С. 3. Golubeva M.G. [Stressogenic disorders of erythrocytes and their correction with help regulatory peptides] // Progress in Physiological Science. 2018. V. 49. № 1. P. 3.
Зинчук В.В., Полуян И.А., Глуткин С.В. Эффект мелатонина на кислородтранспортную функцию крови, газотрансмиттеры и прооксидантно-антиоксидантный баланс при физической нагрузке // Физиология человека. 2019. Т. 45. № 6. С. 124. Zinchuk V.V., Poluyan I.A., Hlutkin S.V. Effects of melatonin on the oxygen transport in blood, gas transmitters, and prooxidant–antioxidant balance in the exercise // Human Physiology. 2019. V. 45. № 6. P. 693.
Тихомирова И.А., Петроченко Е.П., Петроченко А.С. Сероводород как сигнальная молекула в сердечно-сосудистой системе // Регионарное кровообращение и микроциркуляция. 2021. Т. 20. № 1. С. 5. Tikhomirova I.A., Petrochenko E.P., Petrochenko A.S. [Hydrogen sulfide as a signaling molecule in the cardiovascular system] // Regional Blood Circulation and Microcirculation. 2021. V. 20. № 1. P. 5.
Пырочкин В.М., Глуткина Н.В. Механизмы транспорта кислорода и свободнорадикального окисления липидов при инфаркте миокарда в сочетании с метаболическим синдромом, сахарным диабетом 2-го типа. М.: Новое знание, 2014. 136 с. Pyrochkin V.M., Glutkina N.V. [Mechanisms of oxygen transport and free radical lipid oxidation in myocardial infarction in combination with metabolic syndrome, type 2 diabetes mellitus]. M.: New Knowledge, 2014. 136 p.
Wang G., Huang Y., Zhang N. et al. Hydrogen Sulfide Is a Regulator of Hemoglobin Oxygen-Carrying Capacity via Controlling 2,3-BPG Production in Erythrocytes // Oxid. Med. Cell. Longev. 2021. V. 2021. P. 8877691.
Webb K.L., Dominelli P.B., Baker S.E. et al. Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia // Front. Physiol. 2022. V. 12. P. 763 933.