Transgenerational inheritance of longevity: Theoretical framework and empirical evidence

详细

A number of experimental and epidemiological investigations have provided evidence that the health status and aging rate may largely depend on the conditions of early development. Several recent studies provided data suggesting that effects of stresses in early development can be inherited transgenerationally, causing changes of various characteristics in subsequent generations. It has been shown that epigenetic factors associated with regulation of genetic expression, including DNA methylation and modifications of histones and microRNAs, can play a key role in transgenerational inheritance. Until now, it has been generally accepted that the complete erasure of epigenetic marks takes place during gametogenesis and early embryogenesis. In recent years, however, several papers obtained data demonstrating that, in certain cases, epigenetic modifications induced during early ontogenesis could not be erased completely and be transmitted to descendants, affecting their phenotype over several generations. This review provides data of epidemiological and experimental studies showing the possibility of transgenerational inheritance of life expectancy and longevity-associated traits in several generations.