Убиквитин-протеасомная система в регуляции клеточной плюрипотентности и дифференцировки
- Авторы: Поденкова У.И.1, Зубарев И.В.1, Томилин А.Н.1, Цимоха А.С.1
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Учреждения:
- Институт цитологии РАН
- Выпуск: Том 65, № 3 (2023)
- Страницы: 232-245
- Раздел: Статьи
- URL: https://journals.rcsi.science/0041-3771/article/view/140083
- DOI: https://doi.org/10.31857/S0041377123030069
- EDN: https://elibrary.ru/VDOROR
- ID: 140083
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Аннотация
Эмбриональные стволовые клетки (ЭСК) и индуцированные плюрипотентные стволовые клетки (иПСК) демонстрируют уникальную способность к непрерывному самообновлению и дифференцировке во все типы соматических клеток. Понимание механизмов, контролирующих эти свойства, приблизит к эффективному и безопасному использованию ЭСК и иПСК в клеточной терапии. Недавние совокупные данные подчеркнули важность протеостаза в поддержании функции ЭСК. Настоящий обзор посвящен роли убиквитин-протеасомной системы (УПС) – ключевого участника сети протеостаза – в регуляции плюрипотентности и дифференцировки ЭСК и иПСК.
Об авторах
У. И. Поденкова
Институт цитологии РАН
Email: atsimokha@incras.ru
Россия, 194064, Санкт-Петербург
И. В. Зубарев
Институт цитологии РАН
Email: atsimokha@incras.ru
Россия, 194064, Санкт-Петербург
А. Н. Томилин
Институт цитологии РАН
Email: atsimokha@incras.ru
Россия, 194064, Санкт-Петербург
А. С. Цимоха
Институт цитологии РАН
Автор, ответственный за переписку.
Email: atsimokha@incras.ru
Россия, 194064, Санкт-Петербург
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