Prognostic impact of uric acid in patients with acute decompensated heart failure
- 作者: Nasonova S.1, Lapteva A.1, Zhirov I.1,2, Mindzaev D.1, Tereshchenko S.1,2
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隶属关系:
- National Medical Research Center of Cardiology
- Russian Medical Academy of Continuous Professional Education
- 期: 卷 93, 编号 9 (2021)
- 页面: 1066-1072
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/82973
- DOI: https://doi.org/10.26442/00403660.2021.09.201033
- ID: 82973
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Aim. To evaluate the prognostic impact of serum uric acid (SUA) on clinical outcomes in patients with acute decompensated heart failure, as well as identify the correlation between hyperuricemia and renal function and diuretic resistance in these patients.
Materials and methods. The study included 175 patients (125 men and 50 women) with NYHA class II–IV acute decompensated heart failure. Median age was 64 (56–75) years. The Information regarding the survival was obtained 3 years after the admission by telephone calls.
Results. 57 patients reached the end point (death from all causes); therefore, all patients were divided into groups: "alive", "dead". The SUA levels did not differ in the groups. The only significant difference in the studied parameters was the estimated glomerular filtration rate (eGFR), which was significantly higher in the "alive" group [70.5 (52.8–94) and 56 (40–79), respectively; p=0.006]. A moderate negative correlation was found between SUA levels and eGFR in the correlation analysis (r=-0.313, p<0.001). A comparative analysis showed, that SUA level on admission was significantly higher in patients who subsequently received increased doses of diuretics than in patients with a satisfactory response to standard doses of diuretics [567.8 (479.6–791.9) and 512 (422.4–619.4), respectively; p=0.011]. Also, higher eGFR level on admission was observed in patients from the normal SUA level group than in patients from the hyperuricemia group [94 (74.5–101.5) and 63 (48.8–81.3), respectively; p=0.002].
Conclusion. We found no significant differences in the uric acid level in patients who reached the end point and those who did not reach it during the three-year follow-up. However, the found correlation between uric acid levels and diuretic resistance calls for further research.
作者简介
Svetlana Nasonova
National Medical Research Center of Cardiology
Email: anastasiyalapteva95@gmail.com
ORCID iD: 0000-0002-0920-7417
канд. мед. наук, ст. науч. сотр. отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии»
俄罗斯联邦, MoscowAnastasiya Lapteva
National Medical Research Center of Cardiology
Email: anastasiyalapteva95@gmail.com
ORCID iD: 0000-0002-9260-9520
клин. ординатор отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии»
俄罗斯联邦, MoscowIgor Zhirov
National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education
Email: anastasiyalapteva95@gmail.com
ORCID iD: 0000-0002-4066-2661
д-р мед. наук, вед. науч. сотр. отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии», проф. каф. кардиологии ФГБОУ ДПО РМАНПО
俄罗斯联邦, Moscow; MoscowDzambolat Mindzaev
National Medical Research Center of Cardiology
编辑信件的主要联系方式.
Email: anastasiyalapteva95@gmail.com
ORCID iD: 0000-0002-2236-3959
аспирант отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии»
俄罗斯联邦, MoscowSergey Tereshchenko
National Medical Research Center of Cardiology; Russian Medical Academy of Continuous Professional Education
Email: anastasiyalapteva95@gmail.com
ORCID iD: 0000-0001-9234-6129
д-р мед. наук, проф., рук. отд. заболеваний миокарда и сердечной недостаточности ФГБУ «НМИЦ кардиологии», зав. каф. кардиологии ФГБОУ ДПО РМАНПО
俄罗斯联邦, Moscow; Moscow参考
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