The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity
- 作者: Kytikova O.1, Antonyuk M.1, Gvozdenko T.1, Novgorodtseva T.1
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隶属关系:
- Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment
- 期: 卷 93, 编号 3 (2021)
- 页面: 327-332
- 栏目: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/64978
- DOI: https://doi.org/10.26442/00403660.2021.03.200659
- ID: 64978
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详细
The combined course of bronchial asthma (BA) and obesity is one of the urgent medical and social problems that requires a comprehensive and careful study in connection with a decrease in the quality of life of such patients, an increase in the frequency, duration of hospitalization and a high economic burden for the state as a whole. The relationship between BA and obesity is now confirmed by numerous studies, at the same time, despite the variability of the proposed mechanisms of pathogenetic effects of obesity on asthma, metabolic aspects of the relationship of these diseases need further study. Adipose tissue hormones are responsible for the energy homeostasis of the body therefore, excessive accumulation of adipose tissue is accompanied by the development of an imbalance in metabolic processes in various organs and tissues. Due to the emergence of new scientific data on the role and function of adipokines in the body, metabolic effects of adipokines are considered in the focus of their pathophysiological association with obesity and asthma. This literary review highlights the current understanding of the role of metabolic effects of the most studied adipokines (resistin, retinol-binding protein, leptin and adiponectin) in the development of obesity and BA. Gender and age-dependent features of adipokine levels in BA and obesity are described. Data on the confirmed role of adiponectin and leptin in the progression of BA combined with obesity are presented. It has been shown that the role of resistin and retinol-binding protein in the development of BA combined with obesity has not been studied. It is demonstrated that further study of metabolic activity of adipokines in BA is an actual and perspective direction of researches which will allow to develop new diagnostic and therapeutic strategies in patients with BA with obesity.
作者简介
Oksana Kytikova
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment
编辑信件的主要联系方式.
Email: kytikova@yandex.ru
ORCID iD: 0000-0001-5018-0271
д.м.н., науч. сотр. лаб. восстановительного лечения
俄罗斯联邦, VladivostokMarina Antonyuk
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment
Email: kytikova@yandex.ru
ORCID iD: 0000-0002-2492-3198
д.м.н., проф., зав. лаб. восстановительного лечения
俄罗斯联邦, VladivostokTatiana Gvozdenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment
Email: kytikova@yandex.ru
ORCID iD: 0000-0002-6413-9840
д.м.н., проф. РАН, гл. науч. сотр. лаб. восстановительного лечения
俄罗斯联邦, VladivostokTatiana Novgorodtseva
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration – Institute of Medical Climatology and Rehabilitative Treatment
Email: kytikova@yandex.ru
ORCID iD: 0000-0002-6058-201X
д.б.н., проф., гл. науч. сотр. лаб. биомедицинских исследований
俄罗斯联邦, Vladivostok参考
- Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2014.
- Peterson CM, Su H, Thomas DM, et al. Tri-Ponderal Mass Index vs Body Mass Index in Estimating Body Fat During Adolescence. JAMA Pediatr. 2017;171:629-36. doi: 10.1001/jamapediatrics.2017.0460
- Кытикова О.Ю., Гвозденко Т.А., Антонюк М.В. Современные аспекты распространенности хронических бронхолегочных заболеваний. Бюл. физиологии и патологии дыхания. 2017;64:94-100 [Kytikova OYu, Gvozdenko TA, Antonyuk MV. Modern aspects of prevalence of chronic bronchopulmonary diseases. . Bulletin of Respiratory Physiology and Pathology. 2017;64:94-100 (In Russ.)]. doi: 10.12737/article_5936346fdfc1f3.32482903
- Dumas O, Varraso R, Gillman MW, et al. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy. 2016;71:1295-304. doi: 10.1111/all.12876
- Кытикова О.Ю., Гвозденко Т.А., Антонюк М.В. Роль системного воспаления при бронхиальной астме и ожирении. Клин. мед. 2018;96(9):784-90 [Kytikova OYu, Gvozdenko TA, Antonyuk MV. The role of systemic inflammation in bronchial asthma and obesity. Klin. med. 2018;96(9):784-90 (In Russ.)].
- Forno Е. Moving Beyond the Confines of Body Mass Index in the Quest to Understand Obese Asthma. Am J Respir Crit Care Med. 2020;201(3):271-2. doi: 10.1164/rccm.201910-2031ED
- Kang M, Sohn S-J, Shin M-H. Association between Body Mass Index and Prevalence of Asthma in Korean Adults. Chonnam Med J. 2020;56(1):62-7. doi: 10.4068/cmj.2020.56.1.62
- Huang F, Del-Río-Navarro BE, Torres-Alcántara S, et al. Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. J Asthma. 2017;54(2):153-61.doi: 10.1080/02770903.2016.1200611
- Sideleva O, Suratt B, Black K, et al. Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med. 2012;186(7):598-605. doi: 10.1164/rccm.201203-0573oc
- Кытикова О.Ю. Взаимоотношения иммунной, липопероксидной и антиоксидантной систем при хроническом воспалении. Международный журнал экспериментального образования. 2014;8:64-5 [Kytikova OYu. The relationship of the immune, lipoperoxide and antioxidant systems in chronic inflammation. International Journal of Experimental Education. 2014;8:64-5 (In Russ.)].
- Maniscalco M, Paris D, Melck DJ, et al. Coexistence of obesity and asthma determines a distinct respiratory metabolic phenotype. J Allergy Clin Immunol. 2017;139:1536-47.e5. doi: 10.1016/j.jaci.2016.08.038
- Кытикова О.Ю. Антонюк М.В., Гвозденко Т.А., Новгородцева Т.П. Метаболические аспекты взаимосвязи ожирения и бронхиальной астмы. Ожирение и метаболизм. 2018;15 (4):9-14 [Kytikova OYu, Antonyuk MV, Gvozdenko TA, Novgorodceva TP. Metabolic aspects of the relationship between obesity and bronchial asthma. Ozhirenie i metabolizm. 2018;15 (4):9-14 (In Russ.)].doi: 10.14341/omet9578
- De Lima Azambuja R, da Costa Santos Azambuja L, Costa S, et al. Adiponectin in asthma and obesity: protective agent or risk factor for more severe disease? Lung. 2015;193(5):749-55.doi: 10.1007/s00408-015-9793-8
- Kwak S, Kim YD, Na HG, et al. Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells. Biochem Biophys Res Commun. 2018. pii: S0006-291X(18)30735-6. doi: 10.1016/j.bbrc.2018.03.206
- Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol Metab. 2011;22:259-65.doi: 10.1016/j.tem.2011.03.005
- Osborne LC, Joyce KL, Alenghat T, et al. Resistin-like molecule alpha promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. J Immunol. 2013;190:2292-300.doi: 10.4049/jimmunol.1200706
- Kang S, Chemaly ER, Hajjar RJ, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011;286:18465-73.doi: 10.1074/jbc.m110.200022
- Jiang S, Park DW, Tadie JM, et al. Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol. 2014;192(10):4795-803. doi: 10.4049/jimmunol.1302764
- Pirvulescu M, Manduteanu I, Gan AM, et al. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation. Biochem Biophys Res Communications. 2012;422:321-6. doi: 10.1016/j.bbrc.2012.04.159
- Fang C, Meng Q, Wu H. Resistin-like molecule-β is a human airway remodelling mediator. Eur Respir J. 2012;39(2):458-66.doi: 10.1183/09031936.00107811
- Ballantyne D, Scott H, MacDonald-Wicks L, et al. Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma. Clin Exp Allergy. 2016;46(8):1056-65.doi: 10.1111/cea.12742
- Kim KW, Shin YH, Lee KE, et al. Relationship between adipokines and manifestations of childhood asthma. Ped Allergy Immunol. 2008;19(6):535-40. doi: 10.1111/j.1399-3038.2007.00690.x
- Вербовой А.Ф., Косарева О.В., Ахмерова Р.И. Лептин, резистин и гормонально-метаболические показатели у женщин с сахарным диабетом 2-го типа и при его сочетании с бронхиальной астмой. Терапевтический архив. 2015;87(10):37-41 [Verbovoy AF, Kosareva OV, Akhmerova RI. Leptin, resistin, and hormonal and metabolic parameters in women with type 2 diabetes and in those with its concurrence with asthma. Terapevticheskii Arkhiv (Ter. Arkh.). 2015;87(10):37-41 (In Russ.)]. doi: 10.17116/terarkh2015871037-41
- Blaner WS. Retinol-binding protein: The serum transport protein for vitamin A. Endocr Rev. 1989;10:308-16. doi: 10.1210/edrv-10-3-308
- Klisić A, Kavarić N, Bjelaković B, et al. The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls. Acta Clin Croat. 2017;56(1):92-8. doi: 10.20471/acc.2017.56.01.14
- Ulgen F, Herder C, Kühn MC, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem. 2010;116:57-62.doi: 10.3109/13813451003631421
- Lee S-A, Yuen JJ, Jiang H, et al. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016;64:1534-46. doi: 10.1002/hep.28659
- Majerczyk M, Kocełak P, Choręza P, et al. Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4(RBP4) in a cohort of people aged 65 years and older. J Endocrinol Invest. 2018. doi: 10.1007/s40618-018-0856-6
- Comerford KB, Buchan W, Karakas SE. The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res. 2014;46:224-31. doi: 10.1055/s-0033-1353204
- Park YH, Kim KW, Lee KE, et al. Clinical implications of serum retinol-binding protein 4 in asthmatic children. J Korean Med Sci. 2009;24(6):1010-4. doi: 10.3346/jkms.2009.24.6.1010
- Yamamoto R, Ueki S, Moritoki Y, et al. Adiponectin attenuates human eosinophil adhesion and chemotaxis: implication in allergic inflammation. J Asthma. 2013;50(8):828-35. doi: 10.3109/02770903.2013.816725
- Palit SP, Patel R, Jadeja SD, et al. A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes. Sci Rep. 2020;10(1):2904. doi: 10.1038/s41598-020-59845-z
- Ishida M, Tatsumi K, Okumoto K, Kaji H. Adipose tissue-derived stem cell sheet improves glucose metabolism in obese mice. Stem Cells Dev. 2020. doi: 10.1089/scd.2019.0250
- Sood A, Shore SA. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J Allergy. 2013; p. 1–15.doi: 10.1155/2013/785835
- Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Адипонектин в плазме крови при бронхиальной астме. Уральский научный вестник. 2014;34(113):34-41 [Mineev VN, Lalaeva TM, Vasil’eva TS, Kuz’mina AA. Plasma adiponectin in asthma. 2014;34(113):34-41 (In Russ.)] doi: 10.24884/1607-4181-2014-21-3-34-40
- Nigro E, Daniele A, Scudiero O, et al. Adiponectin in Asthma: Implications for Phenotyping. Curr Protein Pept Sci. 2015;16(3):182-7.doi: 10.2174/1389203716666150120095342
- Sutherland TJT, Sears MR, McLachlan CR, et al. Leptin, adiponectin, and asthma: findings from a population-based cohort study. Ann Allergy Asthma Immunol. 2009;103(2):101-7. doi: 10.1016/s1081-1206(10)60161-5
- Nagel G, Koenig W, Rapp K, et al. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Ped Allergy Immunol. 2009;20(1):81-8. doi: 10.1111/j.1399-3038.2008.00740.x
- Ma C, Wang Y, Xue M. Correlations of severity of asthma in children with body mass index, adiponectin and leptin. J Clin Lab Anal. 2019;33(6):e22915. doi: 10.1002/jcla.22915
- Кириллова О.О., Ворожко И.В., Гаппарова К.М., и др. Адипокины и метаболизм ключевых пищевых веществ у больных с ожирением. Терапевтический архив. 2014;86(1):45-8 [Kirillova OO, Vorozhko IV, Gapparova KM, et al. Adipokines and the metabolism of key nutrients in patients with obesity. Terapevticheskii Arkhiv (Ter. Arkh.). 2014;86(1):45-8 (In Russ.)].
- Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18:363-74. doi: 10.1038/nm.2627
- Muc M, Todo-Bom A, Mota-Pinto A, et al. Leptin and resistin in overweight patients with and without asthma. Allergol Immunopathol (Madr). 2014;42(5):415-21. doi: 10.1016/j.aller.2013.03.004
- Souza-Almeida G, D’Avila H, Almeida PE, et al. Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1. Front Immunol. 2018;9:111. doi: 10.3389/fimmu.2018. 00111
- Tsaroucha A, Daniil Z, Malli F, et al. Leptin, adiponectin and ghrelin levels in female patients with asthma during stable and exacerbation periods. J Asthma. 2013;50(2):188-97. doi: 10.3109/02770903.2012.747101
- Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Роль адипокинов при бронхиальной астме. В кн.: Сборник трудов IX Всероссийской научно-практической конференции «Здоровье – основа человеческого потенциала. Проблемы и пути их решения». 2014; с. 532-3 [Mineev VN, Lalaeva TM, Vasil’eva TS, Kuz’mina AA. The role of adipokines in bronchial asthma. In the book: Proceedings of the IX All-Russian Scientific and Practical Conference "Health-the basis of human potential. Problems and ways to solve them". 2014; p. 532-3 (In Russ.)].
- Gurkan F, Atamer Y, Ece A, et al. Serum leptin levels in asthmatic children treated with an inhaled corticosteroid. Ann Allergy Asthma Immunol. 2004;93(3):277-80. doi: 10.1016/s1081-1206(10)61501-3
- Lessard A, St-Laurent J, Turcotte H, Boulet L-P. Leptin and adiponectin in obese and non-obese subjects with asthma. Biomarkers. 2011;16(3):271-3. doi: 10.3109/1354750x.2010.550013
- Dixon AE, Johnson SE, Griffes LV. Relationship of adipokines with immune response and lung function in obese asthmatic and non-asthmatic women. J Asthma. 2011;48(8):811-7.doi: 10.3109/02770903.2011.613507
- Чубриева С.Ю., Глухов Н.В., Зайчик А.М. Жировая ткань как эндокринный регулятор. Вестн. С.-Петерб. ун-та. 2008;11(1):1-43 [Chubrieva SJu, Gluhov NV, Zaĭchik AM. Adipose tissue as an endocrine regulator. Vestn. S.-Peterb. un-ta. 2008;11(1):1-43 (In Russ.)].
- Seoane-Collazo P, Martínez-Sánchez N, Milbank E, Contreras C. Incendiary Leptin. Nutrients. 2020;12(2). pii: E472. doi: 10.3390/nu12020472
- Suratt BT, Ubags NDJ, Rastogi D, et al. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017;14:1050-9. doi: 10.1513/AnnalsATS.201703-263WS
- Yu Q, Wang D, Wen X, et al. Adipose-derived Exosomes Protect the Pulmonary Endothelial Barrier in Ventilator-induced Lung Injury by Inhibiting the TRPV4/Ca2+ Signaling Pathway. Аm J Physiol Lung Cell Mol Physiol. 2020. doi: 10.1152/ajplung.00255.2019