Anemia as a risk factor of contrast-associated acute kidney injury
- 作者: Mironova O.1, Deev A.2, Lakotka P.1, Fomin V.1
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隶属关系:
- Sechenov First Moscow State Medical University (Sechenov University)
- National Research Center for Therapy and Preventive Medicine
- 期: 卷 92, 编号 12 (2020)
- 页面: 48-52
- 栏目: Articles
- URL: https://journals.rcsi.science/0040-3660/article/view/60255
- DOI: https://doi.org/10.26442/00403660.2020.12.200450
- ID: 60255
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Aim. The aim of our study was to assess the role of anemia as a risk factor of contrast-associated acute kidney injury (CA-AKI) in patients with stable coronary artery disease.
Materials and methods. 1023 patients with chronic coronary artery disease were enrolled in a prospective, open, cohort study (ClinicalTrials.gov ID NCT04014153). 83 patients had anemia. CA-AKI was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dl or more in serum creatinine from baseline value, assessed at 48 hours following the administration of the contrast. The primary endpoint of the study was the development of CA-AKI according to KDIGO criteria.
Results. CA-AKI developed in 12 (14.5%) patients with anemia according to the relative increase of the level of serum creatinine (25% and more from the baseline). With using the absolute increase of the level of serum creatinine the prevalence of CA-AKI was 2 (2.4%) patients. Patients with anemia had higher rate of CA-AKI than the overall population of the study (14.4% versus 12.7%). Although our results were not statistically significant (р=0.61, odds ratio 1.19, 95% confidence interval 0.63–2.24).
Conclusion. The prevalence of CA-AKI was higher in the group of patients with anemia, but didn’t meet statistical significance and needs further evaluation in larger studies.
作者简介
O. Mironova
Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: mironova_o_yu@staff.sechenov.ru
ORCID iD: 0000-0002-5820-1759
к.м.н., доц. каф.
俄罗斯联邦, MoscowA. Deev
National Research Center for Therapy and Preventive Medicine
Email: mironova_o_yu@staff.sechenov.ru
ORCID iD: 0000-0002-7669-9714
к.ф.-м.н., вед. науч. сотр.
俄罗斯联邦, MoscowP. Lakotka
Sechenov First Moscow State Medical University (Sechenov University)
Email: mironova_o_yu@staff.sechenov.ru
ORCID iD: 0000-0002-6055-7375
аспирант
俄罗斯联邦, MoscowV. Fomin
Sechenov First Moscow State Medical University (Sechenov University)
Email: mironova_o_yu@staff.sechenov.ru
ORCID iD: 0000-0002-2682-4417
чл.-кор. РАН, д.м.н., проф., проректор, зав. каф.
俄罗斯联邦, Moscow参考
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