Association of rs3025058 polymorphism with the development of stroke in patients with cardiovascular pathology
- 作者: Nikulina S.1, Shulman V.1, Chernova A.1,2, Prokopenko S.1, Nikulin D.1,3, Platunova I.4, Tretyakova S1, Semenchukov A.1, Marilovtseva O.1, Lebedeva I.1, Maksimov V.5, Gurazheva A.5
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隶属关系:
- Voino-Yasenetsky Krasnoyarsk State Medical University
- Berzon Krasnoyarsk Interdistrict Clinical Hospital №20
- Federal Siberian Research Clinical Center
- Berzon Krasnoyarsk Interdistrict Clinical Hospital №20, Krasnoyarsk
- Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
- 期: 卷 92, 编号 12 (2020)
- 页面: 25-30
- 栏目: Articles
- URL: https://journals.rcsi.science/0040-3660/article/view/60250
- DOI: https://doi.org/10.26442/10.26442/00403660.2020.12.200437
- ID: 60250
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Aim. To study the association of single-nucleotide polymorphism rs3025058 (5а/6а) with the development of stroke in patients of the East Siberian population with cardiovascular pathology and risk factors for its development.
Materials and methods. The study involved 260 patients with stroke (age [57.0; 51.0–62.0]) and 272 patients of the control group (age [55.0; 51.0–62.0]). Among the patients who underwent stroke, 157 men and 103 women. The control group included 170 men and 102 women. The examination of the main group included: collection of complaints, anamnesis, clinical examination, computed tomography of the brain, electrocardiography, echocardioscopy, ultrasound duplex scanning of the extracranial brachiocephalic arteries, 24-hour monitoring of blood pressure and heart rate, analysis of the blood coagulation system. The patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of extracranial brachiocephalic arteries, disorders of the hemostasis system. The control group was examined within the framework of the international project HAPIEE. Molecular genetic research was carried out by real-time PCR. Statistical processing of the material was carried out using the Statistica for Windows 7.0, Excel and SPSS 22 application software.
Results. The study established statistically significant associations between the 5a/5a genotype and the 5a allele and stroke in the general group of patients, as well as in the subgroup of men, subgroups of patients with extracranial brachiocephalic arteries atherosclerosis and dyslipidemia. In the subgroup of patients with cardiac arrhythmias, statistically significant results were obtained only for allele 5a, and in the subgroup of women with stroke, subgroups of patients with arterial hypertension and hypercoagulation, no significant associations of rs3025058 (5a/6a) polymorphism with stroke were found.
Conclusion. Genotype 5a/5a and allele 5a of the single-nucleotide polymorphism rs3025058 (5а/6а) increase the risk of stroke in individuals from the East Siberian population, including those in the presence of such risk factors as extracranial brachiocephalic arteries atherosclerosis and dyslipidemia.
作者简介
S. Nikulina
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: info@eco-vector.com
ORCID iD: 0000-0002-6968-7627
д.м.н., проф., зав. каф.
俄罗斯联邦, KrasnoyarskV. Shulman
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: info@eco-vector.com
ORCID iD: 0000-0002-1968-3476
д.м.н., проф. каф., председатель
俄罗斯联邦, KrasnoyarskA. Chernova
Voino-Yasenetsky Krasnoyarsk State Medical University; Berzon Krasnoyarsk Interdistrict Clinical Hospital №20
Email: info@eco-vector.com
ORCID iD: 0000-0003-2977-1792
д.м.н., доц. каф., ст. науч. сотр., врач функциональной диагностики
俄罗斯联邦, KrasnoyarskS. Prokopenko
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: info@eco-vector.com
ORCID iD: 0000-0002-4778-2586
д.м.н., проф., зав. каф.
俄罗斯联邦, KrasnoyarskD. Nikulin
Voino-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Research Clinical Center
Email: info@eco-vector.com
ORCID iD: 0000-0003-1591-035X
к.м.н., ассистент каф., врач-терапевт
俄罗斯联邦, KrasnoyarskI. Platunova
Berzon Krasnoyarsk Interdistrict Clinical Hospital №20, Krasnoyarsk
Email: info@eco-vector.com
ORCID iD: 0000-0002-7688-3079
к.м.н., врач-невролог
俄罗斯联邦, KrasnoyarskS Tretyakova
Voino-Yasenetsky Krasnoyarsk State Medical University
编辑信件的主要联系方式.
Email: info@eco-vector.com
ORCID iD: 0000-0003-0529-3001
к.м.н., лаборант
俄罗斯联邦, KrasnoyarskA. Semenchukov
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: info@eco-vector.com
ORCID iD: 0000-0003-4750-8680
науч. сотр.
俄罗斯联邦, KrasnoyarskO. Marilovtseva
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: info@eco-vector.com
ORCID iD: 0000-0002-1323-2367
к.м.н., лаборант
俄罗斯联邦, KrasnoyarskI. Lebedeva
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: info@eco-vector.com
ORCID iD: 0000-0003-2581-0539
лаборант
俄罗斯联邦, KrasnoyarskV. Maksimov
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Email: info@eco-vector.com
ORCID iD: 0000-0002-3157-7019
д.м.н., проф., зав. лаб.
俄罗斯联邦, KrasnoyarskA. Gurazheva
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Email: info@eco-vector.com
ORCID iD: 0000-0003-1547-624X
мл. науч. сотр. лаб.
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