Diffuse large B-cell lymphoma with concomitant c-MYC and BCL6 gene rearrangements with primary skin involvement: A case report and a review of literature
- 作者: Gabeeva N1, Koroleva D1, Belyaeva A1, Chernova N1, Kuzmina L1, Sudarikov A1, Obukhova T1, Kovrigina A1, Zvonkov E1, Savchenko V1
-
隶属关系:
- ФГБУ «Гематологический научный центр» Минздрава России
- 期: 卷 89, 编号 7 (2017)
- 页面: 85-92
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/32297
- DOI: https://doi.org/10.17116/terarkh201789785-92
- ID: 32297
如何引用文章
全文:
详细
关键词
作者简介
N Gabeeva
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
D Koroleva
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
A Belyaeva
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
N Chernova
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
L Kuzmina
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
A Sudarikov
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
T Obukhova
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
A Kovrigina
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
E Zvonkov
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
V Savchenko
ФГБУ «Гематологический научный центр» Минздрава РоссииМосква, Россия
参考
- Morton LM, Turner JJ, Cerhan JR, Linet MS, Treseler PA, Clarke CA, Jack A, Cozen W, Maynadié M, Spinelli JJ, Costantini AS, Rüdiger T, Scarpa A, Zheng T, Weisenburger DD. Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph). Blood. 2007;110:695-708. https://doi.org/10.1182/blood-2006-11-051672
- Swerdlow SH, Campo E, Harris NL, Jaffe, ES, Pileri, SA, Stein, H, Thiele, J, Vardiman, JW. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC; 2008.
- Barrans S, Crouch S, Smith A, Turner K, Owen R, Patmore R, Roman E, Jack A. Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab. J Clin Oncol. 2010;28:3360-3365. https://doi.org/10.1200/JCO.2009.26.3947
- Sietse M. Aukema, Reiner Siebert, Ed Schuuring, Gustaaf W. van Imhoff, Hanneke C. Kluin-Nelemans, Evert-Jan Boerma and Philip M. Kluin. Double-hit B-cell lymphomas. Blood. 2011; 117:2319-2331. https://doi.org/10.1182/blood-2010-09-297879
- Звонков Е.Е. Первичные экстранодальные В-клеточные лимфатические опухоли: клиника, диагностика, лечение. Дисс. ... д-ра мед. наук. М.; 2009. Ссылка активна на 11.12.2016. Доступно по: www.dissercat.com
- Bradford PT1, Devesa SS, Anderson WF, Toro JR. Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood. 2009;113(21):5064-5073. https://doi.org/10.1182/blood-2008-10-184168
- Rein Willemze, Elaine S. Jaffe, Gu¨nter Burg, Lorenzo Cerroni, Emilio Berti, Steven H. Swerdlow, Elisabeth Ralfkiaer, Sergio Chimenti, Jose´ L Diaz-Perez, Lyn M Duncan, Florent Grange, Nancy Lee Harris, Werner Kempf, Helmut Kerl, Michael Kurrer, Robert Knobler, Nicola Pimpinelli, Christian Sander, Marco Santucci, Wolfram Sterry, Maarten H Vermeer, Janine Wechsler, Sean Whittaker, Chris JLM Meijer. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768-3785. https://doi.org/10.1182/blood-2004-09-3502
- Wilcox RA. Cutaneous B-cell lymphomas: 2015 update on diagnosis, risk-stratification, and management. Am J Hematol. 2015;90(1):73-76. https://doi.org/10.1002/ajh.23863
- Илюшкина Е.А., Ковригина А.М., Кравченко С.К., Обухова Т.Н., Воробьев В.И., Звонков Е.Е., Ротанова М.Н., Лапин В.А. Лорие Ю.Ю. Лимфома из клеток мантийной зоны с первичным поражением кожи: клиническое наблюдение. Клиническая онкогематология. Фундаментальные исследования и клиническая практика. 2012;5(2):129-134.
- Willemze R, Meijer CJ, Scheffer E, Kluin PM, Van Vloten WA, Toonstra J, Van der Putte SC. Diffuse large cell lymphomas of follicle center cell origin presenting in the skin: a clinicopathologic and immunologic study of 16 patients. Am J Pathol. 1987;126:325-333. PMCID: PMC1899577
- Grange F, Bekkenk MW, Wechsler J, Meijer CJ, Cerroni L, Bernengo M, Bosq J, Hedelin G, Fink Puches R, van Vloten WA, Joly P, Bagot M, Willemze R. Prognostic factors in primary cutaneous large B-cell lymphomas: A European multicenter study. J Clin Oncol. 2001;19:3602-3610. PMID: 11504742
- Senff NJ, Hoefnagel JJ, Jansen PM, Vermeer MH, van Baarlen J, Blokx WA, Canninga-van Dijk MR, Geerts ML, Hebeda KM, Kluin PM, Lam KH, Meijer CJ, Willemze R. Reclassification of 300 primary cutaneous B-Cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers. J Clin Oncol. 2007;25:1581-1587. https://doi.org/10.1200/JCO.2006.09.6396
- Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Levy R, Wilson W, Grever MR, Byrd JC, Botstein D, Brown PO, Staudt LM. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503-511. https://doi.org/10.1038/35000501
- Juliette J Hoefnagel, Remco Dijkman, Katia Basso, Patty M Jansen, Christian Hallermann, Rein Willemze, Cornelis P Tensen and Maarten H Vermeer. Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling. Blood. 2005;105:3671-3678. https://doi.org/10.1182/blood-2004-04-1594
- Koens L, Zoutman WH, Ngarmlertsirichai P, Przybylski GK, Grabarczyk P, Vermeer MH, Willemze R, Jansen PM, Schmidt CA, Tensen CP. Nuclear factor-kappaB pathway-activating gene aberrancies in primary cutaneous large B-cell lymphoma, leg type. J Invest Dermatol. 2014;134:290-292. https://doi.org/10.1038/jid.2013.265
- Vibha Thomas, Robin Dobson, Robert Mennel. Primary cutaneous large B-cell lymphoma, leg type. Proc (Bayl Univ Med Cent). 2011;24(4):350-353. PMCID: PMC3205164
- Swerdlow SH1, Quintanilla-Martinez L, Willemze R, Kinney MC. Cutaneous B-cell lymphoproliferative disorders: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop. Am J Clin Pathol. 2013;139(4):515-535. https://doi.org/10.1309/AJCPNLC9NC9WTQYY
- Gaidano G, Carbone A. MUM1: a step ahead toward the understanding of lymphoma histogenesis. Leukemia. 2000;14(4):563-566. PMID: 10764139
- Tunyaplin C, Shaffer AL, Angelin-Duclos CD, Yu X, Staudt LM, Calame KL. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J Immunol. 2004;173:1158-1165. PMID: 15240705
- Shaffer AL, Lin KI, Kuo TC, Yu X, Hurt EM, Rosenwald A, Giltnane JM, Yang L, Zhao H, Calame K, Staudt LM. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B-cell gene expression program. Immunity. 2002. PMID: 12150891
- Hoefnagel JJ, Mulder MM, Dreef E, Jansen PM, Pals ST, Meijer CJ, Willemze R, Vermeer MH. Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma. Mod Pathol. 2006;19(9):1270-1276. https://doi.org/10.1038/modpathol.3800650
- Kodama K, Massone C, Chott A, Metze D, Kerl H, Cerroni L. Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients. Blood. 2005;106(7):2491-2497. https://doi.org/10.1182/blood-2005-03-1175
- Juliette J Hoefnagel, Remco Dijkman, Katia Basso, Patty M Jansen, Christian Hallermann, Rein Willemze, Cornelis P Tensen, Maarten H Vermeer, Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling. Blood. 2005;105(9). https://doi.org/10.1182/blood-2004-04-1594
- Koh J, Enders GH, Dynlacht BD, Harlow E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature. 1995;375(6531):506-510. https://doi.org/10.1038/375506a0
- Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996;85(1):27-37. PMID: 8620534
- Dijkman R, Tensen CP, Jordanova ES, Knijnenburg J, Hoefnagel JJ, Mulder AA, Rosenberg C, Raap AK, Willemze R, Szuhai K, Vermeer MH, Array-based comparative genomic hybridization analysis reveals recurrent chromosomal alterations and prognostic parameters in primary cutaneous large B-cell lymphoma. J Clin Oncol. 2006;24(2):296-305. https://doi.org/10.1200/JCO.2005.02.0842
- Ngo VN1, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM. Oncogenically active MYD88 mutations in human lymphoma. Nature. 2011;470. https://doi.org/10.1038/nature09671
- Pham-Ledard A, Beylot-Barry M, Barbe C, Leduc M, Petrella T, Vergier B, Martinez F, Cappellen D, Merlio JP, Grange F. High frequency and clinical prognostic value of MYD88 L265P mutation in primary cutaneous diffuse large B-cell lymphoma, leg-type. JAMA Dermatol. 2014. https://doi.org/10.1001/jamadermatol.2014.821
- Rovira J, Karube K, Valera A, Colomer D, Enjuanes A, Colomo L, Martinez-Trillos A, Gine E, Dlouhy I, Magnano L, Delgado J, Martinez A, Villamor N, Campo E, Lopez-Guillermo A. MYD88 L265P mutations, but no other variants, identify a subpopulation of DLBCL patients of activated B-cell origin, extranodal involvement and poor outcome. Clin Cancer Res. 2016 Jan 20. https://doi.org/10.1158/1078-0432.CCR-15-1525
- Belaud-Rotureau MA, Marietta V, Vergier B, Mainhaguiet G, Turmo M, Idrissi Y, Ferrer J, Beylot-Barry M, Dubus P, Merlio JP. Inactivation of p16INK4a/CDKN2A gene may be a diagnostic feature of large B cell lymphoma leg type among cutaneous B cell lymphomas. Virchows Arch. 2008;452(6):607-620. https://doi.org/10.1007/s00428-008-0593-x
- Sarah Menguy, Audrey Gros, Anne Pham-Ledard, Maxime Battistella, Nicolas Ortonne, François Comoz, Brigitte Balme, Vanessa Szablewski, Laurence Lamant, Agnès Carlotti, Marie-Hélène Lorton, Anne de Muret, François Le Gall, FrédéricFranck, Anne Croue, David Cappellen, Marie Beylot-Barry, Jean-Philippe Merlio, Béatrice Vergier. MYD88 somatic mutation is a diagnostic criterion in primary cutaneous large B-cell lymphoma. The Journal of Investigative Dermatology. 2016. https://doi.org/10.1016/j.jid.2016.04.018
- Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM. Oncogenically active MYD88 mutations in human lymphoma. Nature. 2011; 470(7332):115-119. https://doi.org/10.1038/nature09671
- Horn H, Ziepert M, Becher C, Barth TFE, Bernd H-W, Feller AC, Klapper W, Hummel M, Stein H, Hansmann M, Schmelter C, M¨oller P, Cogliatti S, Pfreundschuh M, Schmitz N, Tr¨umper L, Siebert R, Loeffler M, Rosenwald A, Ott G. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood. 2013;21(2). https://doi.org/10.1182/blood-2012-06-435842
- Hallermann C, Kaune KM, Gesk S, Martin-Subero JI, Gunawan B, Griesinger F, Vermeer MH, Santucci M, Pimpinelli N, Willemze R, Siebert R, Neumann C. Molecular Cytogenetic Analysis of Chromosomal Breakpoints in the IGH, MYC, BCL6, and MALT1 Gene Loci in Primary Cutaneous B-cell Lymphomas. Journal of Investigative Dermatology. 2004;123:213-219. https://doi.org/10.1111/j.0022-202X.2004.22720.x
- Friedberg JW. Double-hit diffuse large B-cell lymphoma. J Clin Oncol. 2012;30:3439-3443. https://doi.org/10.1200/JCO.2012.43.5800
- Sandlund JT, Kastan MB, Kennedy W, Behm F, Entrekin E, Pui CH, Kalwinsky DT, Raimondi SC. A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia. Cancer Genet Cytogenet. 2006;168(1):69-72. https://doi.org/10.1016/j.cancergencyto.2005.12.013
- Wang HY, Bossler AD, Schaffer A, Tomczak E, DiPatri D, Frank DM, Nowell PC, Bagg A. A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma. Cancer Genet Cytogenet. 2007;172(1):45-53. https://doi.org/10.1016/j.cancergencyto.2006.07.016
- Sanders L, Jayne S, Kennedy B, Miall F, Aukema SM, Siebert R, Wagner SD, Dyer MJ. A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome. Case Rep Hematol. 2014;2014:120714. https://doi.org/10.1155/2014/120714
- Pillai RK, Sathanoori M, Van Oss SB, Swerdlow SH. Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas. Am J Surg Pathol. 2013;37(3):323-332. https://doi.org/10.1097/PAS.0b013e31826cebad
- Karlsson A, Deb-Basu D, Cherry A, Turner S, Ford J, Felsher DW. Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression. Proc Natl Acad Sci USA. 2003;100(17):9974-9979. https://doi.org/10.1073/pnas.1732638100
- Le Gouill S, Talmant P, Touzeau C, Moreau A, Garand R, Juge-Morineau N, Gaillard F, Gastinne T, Milpied N, Moreau P, Harousseau JL, Avet-Loiseau H. The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica. 2007;92(10):1335-1342. https://doi.org/10.3324/haematol.11305
- Li S, Lin P, Fayad LE, Lennon PA, Miranda RN, Yin CC, Lin E, Medeiros LJ. B-cell lymphomas with MYC/8q24 rearrangements and IGH/BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome. Mod Pathol. 2012;25(1):145-156. https://doi.org/10.1038/modpathol.2011.147
- Aukema SM, Kreuz M, Kohler CW, Rosolowski M, Hasenclever D, Hummel M, Kuppers R, Lenze D, Ott G, Pott C, Richter J, Rosenwald A, Szczepanowski M, et al. Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma. Haematologica. 2014;99:726-735. https://doi.org/10.3324/haematol.2013.091827
- Oki Y, Noorani M, Lin P, Davis RE, Neelapu SS, Ma L, Ahmed M, Rodriguez MA, Hagemeister FB, Fowler N, Wang M, Fanale MA, Nastoupil L, Samaniego F, Lee HJ, Dabaja BS, Pinnix CC, Medeiros LJ, Nieto Y, Khouri I, Kwak LW, Turturro F, Romaguera JE, Fayad LE, Westin JR. Double-hit lymphoma: the MD Anderson Cancer Center clinical experience. Br J Haematol. 2014;166:891-901. https://doi.org/10.1111/bjh.12982
- Qing Ye, Xu-Monette ZY, Tzankov A, Deng L, Wang X, Manyam GC, Visco C, Montes-Moreno S, Zhang L, Dybkær K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Parsons BM, Møller MB, Piris MA, Winter JN, Medeiros LJ, Hu S, Young KH. Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma. Oncotarget. 2016;7(3):2401-2416. https://doi.org/10.18632/oncotarget.6262
- Petrich AM, Gandhi M, Jovanovic B, Castillo JJ, Rajguru S, Yang DT, Shah KA, Whyman JD, Lansigan F, Hernandez-Ilizaliturri FJ, Lee LX, Barta SK, Melinamani S, Karmali R, Adeimy C, Smith S, Dalal N, Nabhan C, Peace D, Vose J,Evens AM, Shah N, Fenske TS, Zelenetz AD, Landsburg DJ, Howlett C, Mato A, Jaglal M, Chavez JC, Tsai JP,Reddy N, Li S, Handler C, Flowers CR, Cohen JB, Blum KA, Song K, Sun HL, Press O, Cassaday R, Jaso J,Medeiros LJ, Sohani AR, Abramson JS. Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis. Blood. 2014; 124:2354-2361. https://doi.org/10.1182/blood-2014-05-578963
- Le Gouill S1, Talmant P, Touzeau C, Moreau A, Garand R, Juge-Morineau N, Gaillard F, Gastinne T, Milpied N, Moreau P, Harousseau JL, Avet-Loiseau H. The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica. 2007;92(10):1335-1342. https://doi.org/10.3324/haematol.11305
- de Jongea AV, Roosmaa TJA, Houtenbosb I, Vasmeld WLE, van de Heme K, de Boerf JP, van Maaneng T, Lindauer-van der Werfh G, Beekerc A, Timmersi GJ, Schaarj CG, Soesank M, Poddighel PJ, de Jongm D, Chamuleaua MED. Diffuse large B-cell lymphoma with MYC gene rearrangements: Current perspective on treatment of diffuse large B-cell lymphoma with MYC gene rearrangements; case series and review of the literature. European Journal of Cancer. 2016;55:140-146. https://doi.org/10.1016/j.ejca.2015.12.001
- Gupta E, Accurso J, Sluzevich J, Menke DM, Tun HW. Excellent Outcome of Immunomodulation or Bruton’s Tyrosine Kinase Inhibition in Highly Refractory Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type. Rare Tumors. 2015;7:6067. https://doi.org/10.4081/rt.2015.6067