Incidence rate of celiac disease in patients withchronic diarrhea
- 作者: Parfenov A1, Gudkova R1, Krums L1, Sabelnikova E1, Chikunova B1, Bykova S1, Firsova L1, Sivash E1
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隶属关系:
- ЦНИИ гастроэнтерологии, Москва
- 期: 卷 78, 编号 9 (2003)
- 页面: 55-60
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29658
- ID: 29658
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Material and methods. Serum levels of IgA-antibodies to gliadin, endomysium, reticulin and tissue
transglutaminase were examined in 206 patients with CD. Biopsies were obtained from a distal portion
of the duodenum or a proximal portion of the jejunum.
Results. CD was diagnosed in 35 (16.9%) of 206 patients with ChD. The disease was typical in 5
(2.4%) patients and was latent in 30 (14.5%) patients. Antibodies to gliadin, endomysium, reticulin
and tissues transglutaminase in diagnostically significant titers were detected in the serum of all the examinees
with CD. Formation of the antitissue antibodies occurred because of destructive-dystrophic alterations
of the connective tissue of the lamina propria mucosae pointing to the autoimmune nature of
a pathological process in celiac disease.
Conclusion. To diagnose CD in ChD patients, it is necessary to supplement standard examination with
duodenobiopsy, tests for antibodies to gliadin, tissue transglutaminase and to tissue structures - endomysium
and reticulin.
作者简介
A Parfenov
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
R Gudkova
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
L Krums
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
E Sabelnikova
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
B Chikunova
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
S Bykova
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
L Firsova
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
E Sivash
ЦНИИ гастроэнтерологии, МоскваЦНИИ гастроэнтерологии, Москва
参考
- Gomez J.С., Selvaggio G. S., Viola M. et al. Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area. Am. J. Gastroenterol. 2001; 96 (9): 2700-2704.
- Hovell С.J., Collett J. A., Vautier G. et al. High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening? Med. J. Aust. 2001; 175 (5): 247- 250.
- Cook H. В., Burt M. J., Collett J. A. et al. Adult coeliac disease: prevalence and clinical significance. J. Gastroenterol. Hepatol. 2000; 15 (9): 1032-1036.
- Hill I., Fasano A., Schwartz R. et al. The prevalence of celiac disease in at-risk groups of children in the United States. J. Pediatr. 2000; 136: 86-90.
- Ransford R. A., Hayes M., Palmer M., Hall M. J. A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia. J. Clin. Gastroenterol. 2002; 35 (3): 228-233.
- Howard M. R., Turnbull A. J., Morley P. et al. A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency. J. Clin. Pathol. 2002; 55 (10): 754-757.
- Godkin A., Jewell D. The pathogenesis of celiac disease. Gastroenterology, 1998; 115: 206-210.
- Пальцев М. А., Иванов А. А. Межклеточные взаимодействия. M.: Медицина; 1995.
- Collin P. IgA-class transglutaminase antibodies in evaluating the efficacy of gluten-free diet in coeliac disease. Eur. j. gastroenterol. Hepatol. 2002; 14: 311-315.
- Leon F., Camarero С., Репа R. et al. Anti-transglutaminase IgA EL1SA: Clinical potential and drawbacks in celiac disease diagnosis. Am. J. Gastroenterol. 2001; 96(8): 849-853.
- Bruce S. E., Bjarnason I., Peters T. J. Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relator to gliadin and coeliac disease. Clin. Sci. 1985;68:573-579.
- Парфенов А. И. Энтерология. М: Триада-Х; 2002.
- Ferguson A., Arranz E., O'Mahony S. Clinical and pathological spectrum of coeliac disease - active, silent,latent, potential. Gut 1993;34:150-151.
- Frisoni M., Treggiari E. A., et at. Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis. J. Clin. Gastroenterol. 1993;16:16-21.
- Bottaro C., Cataldo F., Rotolo N. et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am. J. Gastroenterol. 1999;94:691-696.
- Sanders D. S., Hurlstone D. P., Stokes R. O. et al. Changing face of adult coeliac disease: experience of a single university hospital in South Yorkshire. Post-grad. Med. J. 2002; 78 (915): 31-33.