Leonid Vasilyevich Sobolev: the first Russian diabetologist, or the History of an unnoticed discovery
- 作者: Salukhov V.1, Khalimov I.2, Shustov S.1, Korovin A.1,3, Churilov L.3
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隶属关系:
- Kirov Military Medical Academy
- Pavlov First Saint Petersburg State Medical University
- Saint Petersburg State University
- 期: 卷 95, 编号 10 (2023)
- 页面: 896-902
- 栏目: History of medicine
- URL: https://journals.rcsi.science/0040-3660/article/view/254730
- DOI: https://doi.org/10.26442/00403660.2023.10.202436
- ID: 254730
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Leonid Vasilyevich Sobolev is an outstanding pathologist, whose name definitely should occupy an honorable place in the galaxy of great scientists of Russia. However, his name was undeservedly forgotten, and the role of his work was underestimated. This Russian scientist made the most important discovery: he proved in an experiment that it is the islets of Langerhans in the pancreas that secrete a humoral regulator, "factor X", the deficiency of which leads to diabetes mellitus. This mysterious islet factor will be isolated from the pancreas of dogs in 1921 by the future Nobel laureate Frederick G. Banting and will become part of the medicine as insulin. However, there is every reason to believe that the discovery of F. G. Banting, who repeated a series of experiments by Leonid Vasilyevich Sobolev, is, in fact, secondary, which is the research subject in this paper.
作者简介
Vladimir Salukhov
Kirov Military Medical Academy
编辑信件的主要联系方式.
Email: vlasaluk@yandex.ru
ORCID iD: 0000-0003-1851-0941
д-р мед. наук, проф., нач. Первой каф. и клиники (терапии усовершенствования врачей) им. акад. Н.С. Молчанова ФГБВОУ ВО «ВМА им. С.М. Кирова»
俄罗斯联邦, Saint PetersburgIurii Khalimov
Pavlov First Saint Petersburg State Medical University
Email: vlasaluk@yandex.ru
ORCID iD: 0000-0002-7755-7275
д-р мед. наук, проф., зав. каф. факультетской терапии им. акад. Г.Ф. Ланга ФГБОУ ВО «Первый СПб ГМУ им. акад. И.П. Павлова»
俄罗斯联邦, Saint PetersburgSergey Shustov
Kirov Military Medical Academy
Email: vlasaluk@yandex.ru
ORCID iD: 0000-0002-9075-8274
д-р мед. наук, проф., проф. Первой каф. и клиники (терапии усовершенствования врачей) им. акад. Н.С. Молчанова ФГБВОУ ВО «ВМА им. С.М. Кирова»
俄罗斯联邦, Saint PetersburgAleksandr Korovin
Kirov Military Medical Academy; Saint Petersburg State University
Email: vlasaluk@yandex.ru
ORCID iD: 0000-0001-5507-6975
д-р мед. наук, доц., преподаватель Первой каф. и клиники (терапии усовершенствования врачей) им. акад. Н.С. Молчанова ФГБВОУ ВО «ВМА им. С.М. Кирова», проф. каф. патологии ФГБОУ ВО СПбГУ
俄罗斯联邦, Saint Petersburg; Saint PetersburgLeonid Churilov
Saint Petersburg State University
Email: vlasaluk@yandex.ru
ORCID iD: 0000-0001-6359-0026
канд. мед. наук, доц., зав. каф. патологии ФГБОУ ВО СПбГУ
俄罗斯联邦, Saint Petersburg参考
- Соболев Л.В. К морфологии поджелудочной железы. Общ. ред. и вступ. статья проф. Д.М. Российского. [М.]: Медгиз, 1950 [Sobolev LV. K morfologii podzheludochnoi zhelezy. Obshch. red. i vstup. stat'ia prof. D.M. Rossiiskogo. [Moscow]: Medgiz, 1950 (in Russian)].
- Салухов В.В., Минаков А.А., Коровин А.Е., и др. Роль Леонида Васильевича Соболева – первооткрывателя инсулина, в изучении атеросклероза в России. Здоровье – основа человеческого потенциала: проблемы и пути их решения. 2022;17(3):1522-31 [Salukhov VV, Minakov AA, Korovin AE, et al. The role of Leonid V. Sobolev, the discoverer of insulin, in the study of atherosclerosis in Russia. Health – the base of human potential: problems and ways to solve them. 2022;17(3):1522-31 (in Russian)].
- Квасов Д.Г., Федорова-Грот А.К. Физиологическая школа И.П. Павлова: портреты и характеристики сотрудников и учеников. Л.: Наука, 1967 [Kvasov DG, Fedorova-Grot AK. Fiziologicheskaia shkola IP Pavlova: portrety i kharakteristiki sotrudnikov i uchenikov. Leningrad: Nauka, 1967 (in Russian)].
- Ssobolew LW. Zur normalen und pathologischen Morphologie der inneren Secretion der Bauchspeicheldrüse. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin. 1902;168:91-128.
- Ssobolew LW. Über die Morphologie der Bauchspeicheldrüse während der Unterbindung ihres Ganges, bei Diabetes und einigen anderen Erkrankungen. Centralblatt f allg Path u path Anat. 1900; Bd. XI, S. 202 (Vorl. Mitteil.).
- Bliss M. The discovery of insulin. Chicago: University of Chicago Press, Toronto: Univ. Press – McClelland & Stewart Ltd., 1982.
- Barron M. The Relation of the Islets of Langerhans to Diabetes with Special Reference to Cases of Pancreatic Lithiasis. Surg Gynecol & Obstet. 1920;31(5):437-48.
- Note by FG Bunting dated Oct 31/20 from loose leaf notebook 1920/21. Available at: https://insulin.library.utoronto.ca/islandora/object/insulin%3AN10002. Accessed: 09.11.2023.
- Ахманов М.С. Леонид Васильевич Соболев, 1876–1919: непризнанный гений. Здоровье – основа человеческого потенциала: проблемы и пути их решения. 2014;9(2):888-902 [Akhmanov MS. Leonid Vasil’evich Sobolev, 1876–1919: an unrewarded genius. Health – the base of human potential: problems and ways to solve them. 2014;9(2):888-902 (in Russian)].
- Баранов В.Г. К истории открытия инсулина. Клиническая медицина. 1949;27(4):21-3 [Baranov VG. K istorii otkrytiia insulina. Klinicheskaia Meditsina. 1949;27(4):21-3 (in Russian)].
- Banting FG, Best CH, Collip JB, et al. Pancreatic extracts in the treatment of diabetes mellitus: preliminary report. Can Med Assoc J. 1922;12(3):141-6.
- Nobel Lecture by Frederick G. Banting. Available at: https://www.nobelprize.org/prizes/medicine/1923/banting/lecture/ Accessed: 09.11.2023.
- Чурилов Л.П., Строев Ю.И., Ахманов М.С. Очерки истории медицины. Биографические эссе. М.: Умный доктор, 2018 [Churilov LP, Stroev IuI, Akhmanov MS. Ocherki istorii meditsiny. Biograficheskie esse. Moscow: Umnyi doktor, 2018 (in Russian)].
- Opie EL. On the relation of chronic interstitial pancreatitis to the islands of Langergans and to diabetes mellitus. J Exp Med. 1901;5(4):397-428. doi: 10.1084/jem.5.4.397
- Whipple AO. Islet cell tumors of the pancreas. Can Med Assoc J. 1952;66(4):334-42.
- Marshall SM. Celebrating 100 years of insulin. Diabetologia. 2021;64(5):944-6. doi: 10.1007/s00125-021-05417-3
- Kinloch N. On Banting, Pavlov and Rabbit Holes. Available at: https://bantinghousenhs.ca/2022/05/25/on-banting-pavlov-and-rabbit-holes/ Accessed: 26.02.2023.
- Banting FG. Ivan Petrovitch Pavlov (1849–1936). Am J Psychiatry. 1936;92(6):1481-4. doi: 10.1176/ajp.92.6.1481