The value and advanced features of pre- and metabiotics in the treatment of symptomatic uncomplicated diverticular colon disease
- 作者: Patsenko M.1, Ardatskaya M.2, Anuchkin A.1, Butorova L.1, Gaivoronsky I.1, Konkova L.1, Levin V.1, Nugaeva N.1, Pavlov A.3,4, Topchiy T.2, Patsenko O.5
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隶属关系:
- Kirov Military Medical Academy – the branch in Moscow
- Central State Medical Academy of the President of the Russian Federation
- National Medical Research Center of High Medical Technologies – Vishnevsky Central Military Clinical Hospital
- Russian Biotechnological University
- Branch No. 1 of National Medical Research Center of High Medical Technologies – Vishnevsky Central Military Clinical Hospital
- 期: 卷 96, 编号 2 (2024)
- 页面: 135-142
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/254710
- DOI: https://doi.org/10.26442/00403660.2024.02.202610
- ID: 254710
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Background. Symptomatic uncomplicated diverticular colon disease (SNDCD) is a common condition that significantly affects the quality of life of patients. One of the main therapeutic targets in SNDCD is the microbiota.
Aim. To evaluate the efficacy and safety of microbiocenosis-based therapy (prebiotic Mucofalk + metabiotic Zakofalk) in relieving symptoms of SNDCD and maintaining asymptomatic remission.
Materials and methods. The study included 60 patients with clinically apparent SNDCD. For 3 months, they were treated with Mukofalk and Zakofalk and then followed up for another 3 months. Parameters such as treatment efficacy, satisfaction and compliance were evaluated, as well as change of short-chain fatty acids in feces using gas-liquid chromatography was measured.
Results. A statistically significant improvement of all assessed symptoms (abdominal pain, constipation, diarrhea, flatulence, tenesmus) was observed after 3 months of therapy. Relapse of abdominal pain and bowel movement disorders (constipation) after completion of therapy were observed in 7 (11.6%) subjects. The compliance study showed that more than 80% of the required number of sachets/tablets was taken by more than 80% of patients. At the end of follow-up, 49 (81.7%) patients rated their outcomes as "excellent" and 11 (18.3%) as "good". During treatment, there was a significant tendency to increase the absolute content of butyric acid in feces.
Conclusion. Microbiocenosis-based therapy with the prebiotic Mukofalk and the metabiotic Zakofalk is effective and safe for treating SNDCD and preventing the recurrence of symptoms and disease complications. The therapy is associated with excellent and good satisfaction and a high compliance to treatment. Therapy with Mukofalk and Zakofalk resulted in the normalization of the intestinal microbiota.
作者简介
Mikhail Patsenko
Kirov Military Medical Academy – the branch in Moscow
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0001-8391-1691
д-р мед. наук, доц., нач. каф. терапии неотложных состояний
俄罗斯联邦, MoscowMaria Ardatskaya
Central State Medical Academy of the President of the Russian Federation
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0001-8150-307X
д-р мед. наук, проф. каф. гастроэнтерологии
俄罗斯联邦, MoscowAleksandr Anuchkin
Kirov Military Medical Academy – the branch in Moscow
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0002-8469-7196
канд. мед. наук, доц., зам. нач. каф. терапии неотложных состояний
俄罗斯联邦, MoscowLudmila Butorova
Kirov Military Medical Academy – the branch in Moscow
编辑信件的主要联系方式.
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0003-4689-2844
канд. мед. наук, преп. каф. терапии неотложных состояний
俄罗斯联邦, MoscowIvan Gaivoronsky
Kirov Military Medical Academy – the branch in Moscow
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0002-7232-6419
канд. мед. наук, доц. каф. терапии неотложных состояний
俄罗斯联邦, MoscowLarisa Konkova
Kirov Military Medical Academy – the branch in Moscow
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0002-0301-8180
канд. мед. наук, доц., доц. каф. терапии неотложных состояний
俄罗斯联邦, MoscowVladimir Levin
Kirov Military Medical Academy – the branch in Moscow
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0002-2089-2961
преп. каф. терапии неотложных состояний
俄罗斯联邦, MoscowNelli Nugaeva
Kirov Military Medical Academy – the branch in Moscow
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0002-1938-7829
канд. мед. наук, преп. каф. терапии неотложных состояний
俄罗斯联邦, MoscowAlexandr Pavlov
National Medical Research Center of High Medical Technologies – Vishnevsky Central Military Clinical Hospital; Russian Biotechnological University
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0003-1836-7946
д-р мед. наук, проф., зам. нач. ФГБУ «НМИЦ ВМТ ЦВКГ им. А.А. Вишневского» по медицинской части, проф. каф. терапии с курсом фармакологии и фармации ФГБОУ ВО «РОСБИОТЕХ»
俄罗斯联邦, Moscow; MoscowTatiana Topchiy
Central State Medical Academy of the President of the Russian Federation
Email: ludmilabutorova@mail.ru
ORCID iD: 0000-0003-4491-881X
канд. мед. наук, доц., доц. каф. гастроэнтерологии
俄罗斯联邦, MoscowOksana Patsenko
Branch No. 1 of National Medical Research Center of High Medical Technologies – Vishnevsky Central Military Clinical Hospital
Email: ludmilabutorova@mail.ru
подполковник медицинской службы, начальник 19-го гастроэнтерологического отд-ния
俄罗斯联邦, Moscow参考
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