Eosinophilic chronic obstructive pulmonary disease: A review
- 作者: Anaev E.1
-
隶属关系:
- Pirogov Russian National Research Medical University
- 期: 卷 95, 编号 8 (2023)
- 页面: 696-700
- 栏目: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/148319
- DOI: https://doi.org/10.26442/00403660.2023.08.202316
- ID: 148319
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详细
Over the past decades, chronic obstructive pulmonary disease (COPD) has become a major public health problem due to increasing morbidity and mortality. COPD is characterized by airflow limitation due to inflammation of the bronchial tree and remodeling of the small airways. In 20–40% of patients with COPD, eosinophilic inflammation of the airways is observed, as in bronchial asthma. Eosinophilic COPD has recently been shown to be a distinct disease and is associated with more pronounced airway remodeling. Although the role of eosinophils in the pathogenesis of COPD is not fully understood, the level of eosinophils can be used in the prognosis and administration of corticosteroids, and their effectiveness is higher in eosinophilia. Currently, monoclonal antibodies directed against interleukins (IL-5, IL-4 and IL-13) or their receptors are being tested in the T2 endotype of COPD. This review focuses on the mechanisms of eosinophilia in COPD, the use of blood and sputum eosinophils as a biomarker, and the advisability of using monoclonal antibodies in the treatment of eosinophilic COPD.
作者简介
Eldar Anaev
Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: el_anaev@hotmail.com
ORCID iD: 0000-0003-3672-9242
д-р мед. наук, проф. каф. пульмонологии фак-та дополнительного профессионального образования ФГАОУ ВО «РНИМУ им. Н.И. Пирогова»
俄罗斯联邦, Moscow参考
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