Pre-exposure prophylaxis of new COVID-19 coronavirus infection with tixagevimab/cilgavimab in adult Moscow patients with primary immunodeficiencies
- 作者: Roppelt A.1,2, Lebedkina M.1, Chernov A.1,3, Kruglova T.1, Mukhina O.1, Yukhnovskaya Y.4, Samedova F.4, Mаrkina U.1, Andrenova G.1, Karaulov A.4, Lysenko M.1,5, Fomina D.1,4
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隶属关系:
- City Clinical Hospital №52
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
- Russian Medical Academy of Continuous Professional Education
- Sechenov First Moscow State Medical University (Sechenov University)
- Pirogov Russian National Research Medical University
- 期: 卷 95, 编号 1 (2023)
- 页面: 78-84
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/133013
- DOI: https://doi.org/10.26442/00403660.2023.01.202088
- ID: 133013
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详细
Background. Primary immunodeficiencies (PIDs), now known as inborn errors of immunity, are a group of inherited diseases caused by defects in the genes that control the immune response. Patients with PIDs have risks of developing a severe course and/or death in COVID-19. Passive immunization with long-acting monoclonal antibodies (MABs) to SARS-CoV-2 should be considered as pre-exposure prophylaxis in patients with PIDs. Tixagevimab/cilgavimab is a combination of MABs that bind to the SARS-CoV-2 spike protein.
Aim. To evaluate the efficacy and safety of pre-exposure prophylaxis of new SARS-CoV-2 infection in PIDs with the combination of tixagevimab/cilgavimab.
Materials and methods. Forty eight patients diagnosed with PIDs were included in the study. Median follow-up after drug administration was 174 days. The total number of confirmed coronavirus infections in patients with PIDs as well as 6 months before and after administration of MAT were assessed.
Results. In the analyzed cohort, the overall incidence of COVID-19 from pandemic onset to MABs administration was 75% (36/48), with 31% (11/36) of over-infected patients having had the infection more than once. The incidence of COVID-19 immediately 6 months before the introduction of tixagevimab/cilgavimab was 40%. All patients who had COVID-19 after pre-exposure prophylaxis had a mild infection. The incidence of COVID-19 6 months after tixagevimab/cilgavimab administration significantly decreased compared to the incidence 6 months before administration (7 and 40%, respectively; p<0.001).
Conclusion. The use of tixagevimab/cilgavimab in patients with PIDs is effective as pre-exposure prophylaxis and reduces the risk of severe COVID-19.
作者简介
Anna Roppelt
City Clinical Hospital №52; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology
编辑信件的主要联系方式.
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0001-5132-1267
канд. мед. наук, врач аллерголог- иммунолог клинико-диагностического отд-ния; мл. науч. сотр. отд. оптимизации лечения иммунодефицитов
俄罗斯联邦, Moscow; MoscowMarina Lebedkina
City Clinical Hospital №52
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-9545-4720
врач – аллерголог-иммунолог отд-ния аллергологии и иммунологии
俄罗斯联邦, MoscowAnton Chernov
City Clinical Hospital №52; Russian Medical Academy of Continuous Professional Education
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0001-6209-387X
мл. науч. сотр. Научно-исследовательского института молекулярной и персонализированной медицины; врач-терапевт отд. клинической фармакологии
俄罗斯联邦, Moscow; MoscowTatiana Kruglova
City Clinical Hospital №52
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-4949-9178
врач – аллерголог-иммунолог, зав. отд-нием аллергологии и иммунологии
俄罗斯联邦, MoscowOlga Mukhina
City Clinical Hospital №52
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-3794-4991
врач – аллерголог-иммунолог консультативно-диагностического отд-ния
俄罗斯联邦, MoscowYulia Yukhnovskaya
Sechenov First Moscow State Medical University (Sechenov University)
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-0928-2054
клин. ординатор каф. клинической иммунологии и аллергологии Института клинической медицины
俄罗斯联邦, MoscowFarida Samedova
Sechenov First Moscow State Medical University (Sechenov University)
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-0852-7208
клин. ординатор каф. клин. иммунологии и аллергологии Института клинической медицины
俄罗斯联邦, MoscowUlyana Mаrkina
City Clinical Hospital №52
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-6646-4233
врач – аллерголог-иммунолог отд-ния аллергологии и иммунологии
俄罗斯联邦, MoscowGerelma Andrenova
City Clinical Hospital №52
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0001-7053-3900
врач – аллерголог-иммунолог отд-ния аллергологии и иммунологии
俄罗斯联邦, MoscowAlexander Karaulov
Sechenov First Moscow State Medical University (Sechenov University)
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-1930-5424
акад. РАН, д-р мед. наук, проф., зав. лаб. иммунопатологии Института молекулярной медицины, зав. каф. клин. иммунологии и аллергологии Института клинической медицины им. Н.В. Склифосовского
俄罗斯联邦, MoscowMariana Lysenko
City Clinical Hospital №52; Pirogov Russian National Research Medical University
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0001-6010-7975
д-р мед. наук, проф. каф. общей терапии фак-та дополнительного профессионального образования; глав. врач
俄罗斯联邦, Moscow; MoscowDaria Fomina
City Clinical Hospital №52; Sechenov First Moscow State Medical University (Sechenov University)
Email: roppelt_anna@mail.ru
ORCID iD: 0000-0002-5083-6637
канд. мед. наук, доц., доц. каф. клин. иммунологии и аллергологии; рук. Московского городского научно-практического центра аллергологии и иммунологии
俄罗斯联邦, Moscow; Moscow参考
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