Prospects of using the nucleoside analogue riamilovir in patients with SARS-CoV-2 infection
- 作者: Maltsev O.1, Kasyanenko K.1, Kozlov K.1, Zhdanov K.1, Lapikov I.2
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隶属关系:
- Kirov Military Medical Academy
- MIREA – Russian Technological University
- 期: 卷 94, 编号 10 (2022)
- 页面: 1171-1176
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/114790
- DOI: https://doi.org/10.26442/00403660.2022.10.201920
- ID: 114790
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Aim. To evaluate clinical efficacy of nucleoside analogues in therapy of moderate COVID-19 in in-patients.
Materials and methods. Retrospective processing of 108 completed clinical cases with moderate novel coronavirus disease was carried out for the period 2020–2021. The duration of the disease at the time of admission did not exceed three days. Experimental group consisted of 53 patients who, in addition to standard therapy, were prescribed “off-label” riamilovir at a daily dosage of 1250 mg for 5 days by the decision of the medical commission. Comparison group included 55 patients who received a combination of umifenovir and ribavirin as antiviral therapy for 5 days. The duration of the main clinical manifestations of the disease, the indicators of clinical and biochemical blood tests, results of the SARS-CoV-2 virus RNA study using the nucleic acid amplification method (NAAT diagnostics).
Results. Significantly faster achievement of clinical improvement in the group of patients treated with riamilovir was shown, as well as faster sanitation from SARS-CoV-2 virus based on the results of etiological testing.
Conclusion. The use of riamilovir for the treatment of patients with moderate novel coronavirus infection (COVID-19) resulted in a significant reduction of general infectious syndromes and respiratory symptoms. Patients from the experimental group significantly faster achieved clinical recovery and sanitation from the pathogen according to the results of NAAT diagnostics.
作者简介
Oleg Maltsev
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-6286-9946
канд. мед. наук, зам. нач. каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
俄罗斯联邦, Saint PetersburgKristina Kasyanenko
Kirov Military Medical Academy
编辑信件的主要联系方式.
Email: dr.snegur@gmail.com
ORCID iD: 0000-0001-9294-7346
преподаватель каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
俄罗斯联邦, Saint PetersburgKonstantin Kozlov
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-4398-7525
д-р мед. наук, доц., доц. каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
俄罗斯联邦, Saint PetersburgKonstantin Zhdanov
Kirov Military Medical Academy
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-3679-1874
чл.-кор. РАН, д-р мед. наук, проф., нач. каф. инфекционных болезней (с курсом медицинской паразитологии и тропических заболеваний) ФГБВОУ ВО «ВМА им. С.М. Кирова»
俄罗斯联邦, Saint PetersburgIgor Lapikov
MIREA – Russian Technological University
Email: dr.snegur@gmail.com
ORCID iD: 0000-0002-2185-3198
канд. техн. наук, доц. Института кибербезопасности и цифровых технологий РТУ МИРЭА
俄罗斯联邦, Moscow参考
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