Гипервитаминоз В12 - новый маркер и предиктор прогностически неблагоприятных заболеваний
- Авторы: Подзолков В.И.1, Драгомирецкая Н.А.1, Дамбаева О.Ц.1, Аувинен С.Т.1, Медведев И.Д.1
-
Учреждения:
- ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
- Выпуск: Том 91, № 8 (2019)
- Страницы: 160-167
- Раздел: Передовая статья
- URL: https://journals.rcsi.science/0040-3660/article/view/33694
- DOI: https://doi.org/10.26442/00403660.2019.08.000378
- ID: 33694
Цитировать
Полный текст
Аннотация
Ключевые слова
Полный текст
Открыть статью на сайте журналаОб авторах
Валерий Иванович Подзолков
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)д.м.н., проф., зав. каф. факультетской терапии №2 лечебного факультета, директор клиники факультетской терапии УКБ №4; ORCID: 0000-0002-0758-5609 Москва, Россия
Наталья Александровна Драгомирецкая
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Email: dragomiretskaya_natalia@mail.ru
к.м.н., доц. каф. факультетской терапии №2 лечебного факультета; тел: +7(925)519-56-50; e-mail: dragomiretskayanatalia@mail.ru; ORCID: 0000-0002-6531-6255 Москва, Россия
Ольга Цереновна Дамбаева
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)клинический ординатор каф. факультетской терапии №2 лечебного факультета Москва, Россия
Сини Тамара Аувинен
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)студентка Москва, Россия
Иван Дмитриевич Медведев
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)к.м.н., доц. каф. факультетской терапии №2 лечебного факультета; ORCID: 0000-0003-4210-2841 Москва, Россия
Список литературы
- Chiche L, Jean R, Romain F, Roux F, et al. Implications cliniques de la decouverte d’une hypervitaminemie B12 en medecine interne. Rev Med Interne. 2008;29:187-94. doi: 10.1016/j.revmed.2007.07.007
- Arendt J.F.B, Nexo E. Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels. PLoS ONE. 2012;9:e45979. doi: 10.1371/journal.pone.0045979
- Deneuville T, Mario N, Tiev K.P, Toledano C, Josselin-Mahr L, Gain M, et al. Concentration plasmatique elevee de la vitamin B12: un indicateur des maladies hepatiquesou tumorales? Rev Med Interne. 2009;30(Suppl. 2):S73. doi: 10.1016/j.revmed.2012.10.006
- Carmel R, Vasireddy H, Aurangzeb I, George K. High serum cobalamin levels in the clinical setting - clinical associations and holo - transcobalamin changes. Clin Lab Haematol. 2001;23:365-71. doi: 10.1046/j.1365-2257.2001.00134.x
- Chiche L, Mancini J, Arlet J.B, investigateurs. De l’etude BDOSE. Hypervitamineґmies B12 en medecine interne: resultats de l’etude BDOSE. Rev Med Interne. 2009;30(Suppl. 4):S377. doi: 10.1016/j.revmed.2009.10.142
- Воробьева Л.И. Пропионовокислые бактерии и образование витамина В12. М.: МГУ, 1986.
- Herbert V. Recommended dietary intakes (RDI) of vitamin B12 in humans. Am J Clin Nutr. 1987;45:671-8. doi: 10.1093/ajcn/45.4.671
- Fenech M.F, Dresoti I.E, Rinaldi J.R. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis. 1997;18:1329-36. doi: 10.1093/carcin/18.7.1329
- Kapiszewska M, Kalemba M, Wojciech U, Milewicz T. Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study. J Nutr Biochem. 2005;16:467-78. doi: 10.1016/j.jnutbio.2005.01.018
- Solomon L.R. Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Rev. 2007;21:113-30. doi: 10.1016/j.blre.2006.05.001
- Whipple G.H, Hooper C.W, Robscheit F.S. Blood regeneration following anemia. IV. Influence of meat, liver, and various extractives, alone or combined with standard diets. Am J Physiol. 1920;53:236-62. doi: 10.1152/ajplegacy.1920.53.2.236
- Minot G.R, Murphy W.P. Treatment of pernicious anemia by special diet. JAMA. 1926;87:470-6. doi: 10.1001/jama.1926.02680070016005
- Smith E.L. Purification of anti - pernicious anemia factors from liver. Nature. 1948;161:638-9. doi: 10.1038/161638a0
- Rickes E.L, Brink N.G, Koniuszy F.R, Wood T.R, Folkers K. Crystalline vitamin B12. Science. 1948;107:396-7. doi: 10.1126/science.107.2781.396
- Castle W.B. Observations on etiologic relationship of achylia gastrica to pernicious anemia. I. Effect of administration to patients with pernicious anemia of contents of normal human stomach recovered after ingestion of beef muscle. Am J Med Sci. 1929;178:748-64.
- Castle W.B, Heath C.W, Strauss M.B, Heinle R.W. Observations on etiologic relationship of achylia gastrica to pernicious anemia.VI. Site of interaction of food (extrinsic) and gastric (intrinsic) factors: failure of in vitro incubation to produce thermostable hematopoietic principle. Am J Med Sci. 1937;294:618-25.
- Gärsbeck R. Fractionation of human gastric juice and saliva employing starch electrophoresis. Gastroenterologia. 1955;84:99-102. doi: 10.1159/000200176
- Kozyraki R, Fyfe J, Kristiansen M, Gerdes C, et al. The intrinsic factor - vitamin B12 receptor, cubilin, is a high - affinity apolipoprotein A-I receptor facilitating endocytosis of high - density lipoprotein. Nat Med. 1999;5:656-61. doi: 10.1038/9504
- Tanner S.M, Aminoff M, Wright F.A, Liyanarachchi S, et al. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. Nat Genet. 2003;33:426-9. doi: 10.1038/ng1098
- Fyfe F.C, Madsen M, Hojrup P, Christensen E.I, et al. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. Blood. 2004;103:1573-9. doi: 10.1182/blood-2003-08-2852
- Gärsbeck R. Imerslund-Gärsbeck syndrome (selective vitamin B(12) malabsorption with proteinuria). Orphanet J Rare Dis. 2006;1:17. doi: 10.1186/1750-1172-1-17
- André S.E, Serraj K, Zhu J, Vermorken A.J.M. The pathophysiology of elevated vitamin B12 in clinical practice. Q J Med. 2013;106:505-15 doi: 10.1093/qjmed/hct051
- Ermens A.A, Vlasveld L.T, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 2003;36:585-90. doi: 10.1016/j.clinbiochem.2003.08.004
- Lindemans J, Kroes A.C.M, van Geel J, Van Kapel J, et al. Uptake of transcobalamin II - bound cobalamin by HL-60 cells: effects of differentiation induction. J Exp Cell Res. 1989;184:449-60. doi: 10.1016/0014-4827(89)90343-1
- Nicolas J.P, Gueant J.L, Fremont S. Cobalamin binding glycoproteins. In: Bhatt H.R, James V.H.T, Besser G.M, Bottazzo G.F, Keen H, eds. Advances in Thomas Addison’s Diseases. Bristol: Journal of Endocrinology Ltd., 1994. P. 253-67.
- Gärsbeck R. Intrinsic factor and the other vitamin B12 transport proteins. Prog Hematol. 1969;6:233-60.
- Burger R.L, Mehlman C.S, Allen R.H. Human plasma R-type vitamin B12-binding proteins. I. Isolation and characterization of transcobalamin I, transcobalamin III and the normal granulocyte vitamin B12-binding protein. J Biol Chem. 1975;250:7700-6.
- Zittoun J. Cobalamins: an update of fundamental and clinical data. Hematologie. 1996;2:119-29.
- Li N, Seetharam S, Lindemans J, Alpers D.H, Arwert F, Seetharam B. Isolation and sequence analysis of variant forms of human transcobalamin II. Biochim Biophys Acta. 1993;1172:21-30. doi: 10.1016/0167-4781(93)90264-E
- Павлов Ч.В., Дамулин И.В., Шульпекова О.Ю., Андреев Е.А. Неврологические расстройства при дефиците витамина В12. Терапевтический архив. 2019;91(4):122-9. doi: 10.26442/00403660.2019.04.000116
- Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr. 2003;78:131-6. doi: 10.1093/ajcn/78.1.131
- Carmel R. Current concepts in cobalamin deficiency. Annu Rev Med. 2000;51:357-75. doi: 10.1146/annurev.med.51.1.357
- Solomon L.R. More on failures of cobalamin assays in pernicious anemia. N Engl J Med. 2012;367:1570. doi: 10.1056/NEJMc1210169
- Baker H, Leevy C.B, De Angelis B, Frank O, Baker E.R. Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. J Am Coll Nutr. 1998; 17:235-8. doi: 10.1080/07315724.1998.10718752
- Kanazawa S, Herbert V. Total corrinoid, cobalamin and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest. 1985;53:108-10.
- Hagelskjaer L, Rasmussen K. Methylmalonic acid concentration in serum not affected in hepatic disease. Clin Chem. 1992;38:493-5
- Carmel R, Eisenberg L. Serum vitamin B12 and transcobalamin abnormalities in patients with cancer. Cancer. 1977;40:1348-53. doi: 10.1002/1097-0142(197709)40:3%3C1348::AID-CNCR2820400352% 3E3.0.CO;2-Q
- Carmel R. Extreme elevation of serum transcobalamin I in patients with metastatic cancer. N Engl J Med. 1975;292:282-4. doi: 10.1056/NEJM197502062920603
- Gimsing P. Cobalamin metabolism in chronic myelogenous leukemia. Dan Med Bull. 1998;45:459-79.
- Fremont S, Chamigneulle B, Gerard P, Felden P, et al. Blood transcobalamin levels in malignant hepatoma. Tumor Biol. 1991;12:353-9. doi: 10.1159/000217736
- Gimsing P, Hippe E. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast. Scand J Haematol. 1978;21:243-9. doi: 10.1111/j.1600-0609.1978.tb00359.x
- Carmel R, Tatsis B, Baril L. Circulating antibody to transcobalamin II causing retention of vitamin B12 in the blood. Blood. 1977;49:987-1000.
- Bowen R.A, Drake S.K, Vanjani R, Huey E.D, et al. Markedly increased vitamin B12 concentrations attributable to IgG-IgM-vitamin B12 immune complexes. Clin Chem. 2006;52:2107-14. doi: 10.1373/clinchem.2006.073882
- Schwartz M, Bastrup-Madsen P. A new vitamin B12 binding protein in serum causing excessively high serum vitamin B12 values. Scand J Haematol. 1968;5:35-40. doi: 10.1111/j.1600-0609.1968.tb01715.x
- André S.E, Henoun Loukili N, Noel E, Maloisel F, et al. Oral cobalamin (daily dose of 1000 mg) therapy for the treatment of patients with pernicious anemia. An open label study of 10 patients. Curr Ther Res. 2005;66:13-22. doi: 10.1016/j.curtheres.2005.02.001
- Kane S.P, Murray-Lyon I.M, Paradinas F.J, Johnson P.J, et al. Vitamin B12 binding protein as a tumour marker for hepatocellular carcinoma. Gut. 1978;19:1105-9. doi: 10.1136/gut.19.12.1105
- Wheeler K, Pritchard J, Luck W, Rossiter M. Transcobalamin I as a marker for fibrolamellar hepatoma. Med Ped Oncol. 1986;14:227-9. doi: 10.1002/mpo.2950140408
- Salles N, Herrmann F, Sakbani K, Rapin C.H, Sieber C. High vitamin B12 level: a strong predictor of mortality in elderly in patients. J Am Geriatr Soc. 2005;53:917-8. doi: 10.1111/j.1532-5415.2005.53278_7.x
- Gimsing P. The cobalamin forms and analogues in plasma and myeloid cells during the course of chronic myelogenous leukemia related to the clinical condition. Br J Haematol. 1995;89:812-9. doi: 10.1111/j.1365-2141.1995.tb08419.x
- Zittoun J, Farcet J.P, Marquet J, Sultan C, Zittoun R. Cobalamin vitamin B12 (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia. Blood. 1984;63:779-83
- Rachmilewitz D, Rachmilewitz E.A, Polliack A, Herchko C.A. Acute promyelocytic leukemia. A report of five cases with a comment on the diagnostic significance of serum vitamin B12 determination. Br J Haematol. 1972;22:87-92. doi: 10.1111/j.1365-2141.1972.tb08789.x
- Lambert D, Benhayoun S, Adjalla C, Gelot M.M, et al. Alcoholic cirrhosis and cobalamin metabolism. Digestion. 1997;58:64-71. doi: 10.1159/000201425
- Fragasso A. Vitamin B12 Deficiency in Alcoholics. In: Watson R., Preedy V., Zibadi S. (eds). Alcohol, Nutrition, and Health Consequences. Nutrition and Health. Humana Press, Totowa, NJ, 2013. doi: 10.1007/978-1-62703-047-2_10
- Fragasso A, Mannarella C, Ciancio A, Sacco A. Functional vitamin B12 deficiency in alcoholics: an intriguing finding in a retrospective study of megaloblastic anemic patients. Eur J Intern Med. 2010;21:97-100. doi: 10.1016/j.ejim.2009.11.012
- Hofer L.J, Elian K.M. Parenteral vitamin B12 therapy of hyperhomocysteinemia in end - stage renal disease. Med Clin Exp. 2004;27:10-3.
- Reynolds E.H, Bottiglieri T, Laundry M, Stern J, et al. Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. Arch Neurol. 1993;50:739-42. doi: 10.1001/archneur.1993.00540070055015
- Molad Y, Rachmilewitz B, Sidi Y, Pinkhas J, Weinberger A. Serum transcobalamin and transcobalamin levels in systemic lupus erythematosus. Am J Med. 1989;88:141-4. doi: 10.1016/0002-9343(90)90463-N
- Grindulis K.A, Calverley M, Cox C. Rheumatoid arthritis: is serum vitamin B12 high in active disease? J Rheumatol. 1984;11:211-2.
- Kalyoncu U, Buyukasik Y, Akdogan A, Karadag O, et al. Increased serum vitamin B12 levels are associated with adult - onset Still’s disease with reactive macrophage activation syndrome. Joint Bone Spine. 2010;77:131-4. doi: 10.1016/j.jbspin.2009.09.010
- Belousov Y.B. Klinicheskaya farmakologiya i farmakoterapiya. M.: GEOTAR-Media, 2010.-S. 624-626, 855-857.
- Serraj K, Mecili M, Housni I, André S.E. L’hypervitaminemie B12: physiopathologie et interêt en pratique clinique. Press Med. 2011;40:1120-7. doi: 10.1016/j.lpm.2011.08.010