Effect of homocysteine on left ventricular structural and functional parameters in patients on programmed hemodialysis
- Authors: Kharlamova UV1, Il'icheva OE1
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Affiliations:
- Челябинская государственная медицинская академия
- Issue: Vol 85, No 3 (2013)
- Pages: 90-93
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31249
- ID: 31249
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Abstract
AIM: To determine the effect of plasma homocysteine (Hc) on the structure and function of the left ventricle (LV) in patients treated by programmed hemodialysis/MATERIAL AND METHODS: 109 patients on programmed hemodialysis were examined. Blood Hc levels were determined and echocardiography was performed in all the patients/RESULTS: In the patients on programmed hemodialysis, Hc concentrations were significantly higher than in apparently healthy individuals; there was a preponderance of mild (49.5%) and moderate (43.1%) hyperhomocysteinemia. LV hypertrophy was diagnosed in 90.8% of the patients. A positive relationship was found between the concentrations of Hc and the E/A ratio (r=0.34; р=0.05), isovolumetric relaxation time (IRT) (r=0.32; р=0.03), and LV mass (LVM) (r=0.3; p=0.05). Multivariate regression analysis indicated that the level of Hc had an independent impact on the E peak (R2=0.3; р=0.05), LV relative wall thickness (RWT) (R2=0.38; р=0.03), and LV IRT (R2=0.3; р=0.06)/CONCLUSION: Elevated plasma Hc levels were found to be related to LVM, LV RWT, LV IRT, E peak, and E/A ratio, suggesting that Hc had an unfavorable effect on the LV structure and function in patients on hemodialysis.
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##article.viewOnOriginalSite##About the authors
U V Kharlamova
Челябинская государственная медицинская академия
O E Il'icheva
Челябинская государственная медицинская академия
References
- Johnston N., Dargie H., Jardine A. Diagnosis and treatment of coronary artery disease in patients with chronic kidney disease. Heart 2008; 94: 1080-1088.
- Мухин Н.А., Моисеев В.С., Кобалава Ж.Д. и др. Кардиоренальные взаимодействия: клиническое значение и роль в патогенезе заболеваний сердечно-сосудистой системы и почек. Тер арх 2004; 6: 39-46.
- Добронравов В.А., Голубев Р.В. Гипергомоцистеинемия - фактор риска сердечно-сосудистых поражений у диализных больных и в общей популяции. Нефрология 2004; 2: 44-49.
- Austin R.C., Lentz S.R., Werstuck G.H. et al. Role of hyperhomocysteinemia in endotelial dysfunction and atherothrombotic disease. Cell Death Differ 2004; 11: 56-64.
- Sultan N., Khan M.A., Malik S. Effect of folic acid supplementation on homocysteine level in postmenopausal women. J Ayub Med Coll Abbottabad 2007; 19 (4): 78-81.
- Ni M., Zhang X.H., Jiang S.L., Zhang Y. Homocysteinemia as an independent risk factor in the Chinese population at a high risk of coronary artery disease. Am J Cardiol 2007; 100 (3): 455-458.
- Fàcila L., Nuñez Е., Sanchis J. et al. Early determination of homocysteine levels in acute coronary syndromes, is it an independent prognostic factor? Int J Cardiol 2005; 100: 275-279.
- Moreno H., Kuffaty J., Croce N. et al. Homocysteinemia and its relation with risk factor for arterial hypertension. Am J Hypertens 2002; 15: 218.
- Bostom A., Brosnan J.T., Hall B. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclrrosis 1995; 116: 59-62.
- Suliman M.E., Divino Filho J.C., Barany P. et al. Effects of high-dose folic acid and pyridoxine on plasma and erythrocite sulfur amino acids in hemodialisis patients. J Am Soc Nephrol 1999; 10: 1287-1296.
- De Simone G. Left Ventricular Geometry and hypertension in End-Stage Renal Disease. A Mechanical Perspective. J Am Soc Nephrol 2003; 14: 2421-2427.
- Liu X., Luo F., Li J. et al. Homocysteine induces connective tissue grows factor expression in vascular smooth muscle cells. J Thromb Haemost 2008; 6 (1): 184-192.
- Zang C., Cai Y., Adachi M.T. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolder protein response. J Biol Chem 2001; 276: 35867-35874.
- Korandji C., Zeller M., Guilland J.C. et al. Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction. Clin Biochem 2007; 40 (1-2): 66-72.
- Беленков Ю.Н. Ремоделирование левого желудочка: комплексный подход. Сердеч недостат 2002; 4: 161-163.
- Агеев Ф.Т., Овчинников А.Г. Диастолическая дисфункция как проявление ремоделирования сердца. Сердеч недостат 2002; 4: 190-195.