The Influence of the Properties of an Aqueous Medium on Dimegin Aggregation

Resumo

The influence of the properties of an aqueous medium on aggregation of dimegin, photoditazine, and radachlorin is comparatively studied. It is noted that the molar extinction nonlinearly depends on the concentration of photosensitizer in solution and the degree of nonlinearity is different for the pharmaceutical form of solutions and solutions prepared with the use of freeze-dried photosensitizer powders. It is shown that the use of surfactants (Pluronic F-127 and polyvinylpyrrolidone) somewhat reduces problems related to aggregation of photosensitizers under study.