A temperature-compensation mechanism in biochemical oscillation models

详细

Different mechanisms that underlie temperature compensation of the frequency (period) of biochemical self-oscillations are considered. A systemic approach to the elucidation of the molecular nature of temperature compensation of the frequency of biochemical self-oscillations has been characterized as better substantiated. The phenomenon of temperature compensation is not unique for circadian oscillations (“biochemical clocks”) but is rather an inherent property of all multidimensional chemical oscillators. Stages with negative coefficients of control over frequency were shown to be the components of the structure of “presetting generators” of biochemical self-oscillations, and the balancing role of these stages can be considered more important as believed earlier. The calculation of control coefficients showed that the elementary stages make unequal contributions to the mechanism that underlies temperature compensation; therefore, different mutations have dissimilar effects on the temperature compensation of the period of circadian oscillations in the respective mutants.