Study on metronidazole distribution in rectal cancer tissue using application method of administration in experiment in vivo

S. A. Yagubov; G. M. Yankovskii; S. E. Kondakov

doi:10.3103/S0027131416050138

Study on metronidazole distribution in rectal cancer tissue using application method of administration in experiment in vivo

Authors: Yagubov S.A.¹, Yankovskii G.M.¹, Kondakov S.E.²
Affiliations:
1. Blokhin Russian Cancer Research Center
2. Department of Chemistry
Issue: Vol 71, No 5-6 (2016)
Pages: 312-318
Section: Article
URL: https://journals.rcsi.science/0027-1314/article/view/163325
DOI: https://doi.org/10.3103/S0027131416050138
ID: 163325

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Abstract

The distribution of metronidazole in rectal cancer tissue using application method of administration was studied. A comparative evaluation of pharmacokinetic parameters of metronidazole accumulation in the tissues depending on the concentration of the drug in the application mixture was carried out. The generalized actual data on metronidazole distribution in tissue samples (341 sample) obtained during 31 surgery are presented.