Obtaining ultradispersed dioxidine powder modified via cryochemical synthesis and determining its antibacterial activity

Abstract

One way to increase bioavailability and efficiency of drug substances is to decrease their particles up to nanoscale level and to change their crystal structure. A new stable nanoscale form of a polymorphic antibacterial 2,3-bis-(hydroxymethyl)-quinoxaline-N,N′-dioxyde (dioxidine) modification characterized with a gas chromatography, NMR, XRF, TEM, and thermoanalytic methods (TG, DTG, DSC) was obtained via cryochemical synthesis. The new polymorphic dioxidine modification was proved to be more active in growth inhibition processes of gram-positive M. cyaneum 98 and gram-negative E. coli bacterial strains than officinal modification.