Nutrient restriction in combinatory therapy of tumors


Дәйексөз келтіру

Толық мәтін

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Аннотация

The main objective of anticancer treatment is the elimination of degenerated cells by the induction of programmed cell death. Various chemotherapy drugs and radiation are able to activate cell death mechanisms in tumors. However, unfortunately, monotherapy will always be insufficiently effective because of the variety and virulence of tumors, as well as their ability to develop resistance to drugs. Moreover, monotherapy might constrain many negative side effects. Therefore, the combination of different approaches and/or drugs will increase the efficiency of treatment. One such promising approach is the combination of nutrient restriction (NR) and various chemotherapeutic drugs. This approach may not only affect the autophagy but also influence apoptotic cell death. This review is focused on the potential of NR use in anticancer therapy, as well as the molecular mechanisms underlying this approach.

Авторлар туралы

V. Senichkin

Faculty of Basic Medicine

Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991

G. Kopeina

Faculty of Basic Medicine

Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991

A. Zamaraev

Faculty of Basic Medicine

Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991

I. Lavrik

Faculty of Basic Medicine; Department of Translational Inflammation Research

Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991; Magdeburg, 39120

B. Zhivotovsky

Faculty of Basic Medicine; Institute of Environmental Medicine, Division of Toxicology

Хат алмасуға жауапты Автор.
Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991; Stockholm, 17177

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