Nutrient restriction in combinatory therapy of tumors
- Авторлар: Senichkin V.V.1, Kopeina G.S.1, Zamaraev A.V.1, Lavrik I.N.1,2, Zhivotovsky B.D.1,3
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Мекемелер:
- Faculty of Basic Medicine
- Department of Translational Inflammation Research
- Institute of Environmental Medicine, Division of Toxicology
- Шығарылым: Том 50, № 3 (2016)
- Беттер: 362-378
- Бөлім: Reviews
- URL: https://journals.rcsi.science/0026-8933/article/view/162655
- DOI: https://doi.org/10.1134/S0026893316030109
- ID: 162655
Дәйексөз келтіру
Аннотация
The main objective of anticancer treatment is the elimination of degenerated cells by the induction of programmed cell death. Various chemotherapy drugs and radiation are able to activate cell death mechanisms in tumors. However, unfortunately, monotherapy will always be insufficiently effective because of the variety and virulence of tumors, as well as their ability to develop resistance to drugs. Moreover, monotherapy might constrain many negative side effects. Therefore, the combination of different approaches and/or drugs will increase the efficiency of treatment. One such promising approach is the combination of nutrient restriction (NR) and various chemotherapeutic drugs. This approach may not only affect the autophagy but also influence apoptotic cell death. This review is focused on the potential of NR use in anticancer therapy, as well as the molecular mechanisms underlying this approach.
Негізгі сөздер
Авторлар туралы
V. Senichkin
Faculty of Basic Medicine
Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991
G. Kopeina
Faculty of Basic Medicine
Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991
A. Zamaraev
Faculty of Basic Medicine
Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991
I. Lavrik
Faculty of Basic Medicine; Department of Translational Inflammation Research
Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991; Magdeburg, 39120
B. Zhivotovsky
Faculty of Basic Medicine; Institute of Environmental Medicine, Division of Toxicology
Хат алмасуға жауапты Автор.
Email: Boris.Zhivotovsky@ki.se
Ресей, Moscow, 119991; Stockholm, 17177
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