Генетические полиморфизмы, ассоциированные с эффективностью коррекции массы тела: систематический обзор
- Авторы: Егорова Э.С.1, Ахметов И.И.1,2
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Учреждения:
- Казанский государственный медицинский университет
- Научно-исследовательский институт спорта и физических упражнений, Ливерпульский университет им. Джона Мурса
- Выпуск: Том 59, № 8 (2023)
- Страницы: 870-887
- Раздел: ОБЗОРНЫЕ И ТЕОРЕТИЧЕСКИЕ СТАТЬИ
- URL: https://journals.rcsi.science/0016-6758/article/view/134632
- DOI: https://doi.org/10.31857/S0016675823080052
- EDN: https://elibrary.ru/XSUABK
- ID: 134632
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Аннотация
Индивидуальные особенности человека не только обусловливают различия в массе тела, но и детерминируют реакцию организма на диету и двигательную активность. Цель данного систематического обзора – описание генетических маркеров, ассоциированных со снижением массы тела в ответ на немедикаментозные методы лечения ожирения, диетотерапию и физические нагрузки. Приемлемые для включения в систематический обзор интервенционные исследования содержали все необходимые параметры генетического полиморфизма, диеты, физической нагрузки и изменений антропометрических или композиционных показателей тела. 91 статья соответствовала критериям и была включена в данный систематический обзор. Подавляющее число исследований (n = 88) было проведено с использованием ген-кандидатного подхода и только три работы выполнены с применением полногеномного поиска ассоциаций (GWAS). Всего было обнаружено 98 генетических вариантов, из которых 72 маркера ассоциированы с эффективностью диетотерапии и 26 – с индивидуальным ответом на физические нагрузки. Следует отметить, что значимость маркеров была подтверждена независимыми исследованиями только для 10 из 98 генетических вариантов. В ближайшие годы следует ожидать прогресса в этом направлении, результатом которого станет разработка метода индивидуального подбора каждому пациенту типа диеты и физической нагрузки для профилактики и лечения ожирения.
Ключевые слова
Об авторах
Э. С. Егорова
Казанский государственный медицинский университет
Автор, ответственный за переписку.
Email: jastspring@yandex.ru
Россия, 420012, Казань
И. И. Ахметов
Казанский государственный медицинский университет; Научно-исследовательский институт спорта и физических упражнений,Ливерпульский университет им. Джона Мурса
Email: jastspring@yandex.ru
Россия, 420012, Казань; Великобритания, L3 5AF, Ливерпуль
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