Email this article Pilot Study to Detect the Repertoires of T-Cell Receptor Gamma Chains in Patients with Juvenile Schizophrenia
- Authors: Plotnikova M.Y.1,2, Patrikeev A.D.1, Levchenko A.Y.3, Fedorenko O.Y.4, Andreeva T.V.1,2,5, Rogaev E.I.1,2,5
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Affiliations:
- Vavilov Institute of General Genetics Russian Academy of Sciences
- Center for Genetics and Life Sciences, “Sirius” University
- Institute of Translational Biomedicine, Saint-Petersburg State University
- Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
- Lomonosov Moscow State University
- Issue: Vol 59, No 7 (2023)
- Pages: 850-854
- Section: КРАТКИЕ СООБЩЕНИЯ
- URL: https://journals.rcsi.science/0016-6758/article/view/134624
- DOI: https://doi.org/10.31857/S0016675823070081
- EDN: https://elibrary.ru/QPJHMR
- ID: 134624
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Abstract
Disfunction of immune system and neuroinflammation may play a role in pathogenesis of schizophrenia. The role of adaptive immune system has to be elucidated. We present a pilot study to test the methodology of profiling of immune repertoires of the TCR gamma chain by deep sequencing using several patients with juvenile schizophrenia and unaffected control subjects. The clonotype profiles were revealed and their diversity and presumable differences in structure of CDR3 TRG region of functional clones in juvenile schizophrenia and controls were estimated. This approach is perspective for further comprehensive study of changes in adaptive immune system in representative cohorts of patients with different forms of schizophrenia.
Keywords
About the authors
M. Yu. Plotnikova
Vavilov Institute of General Genetics Russian Academy of Sciences; Center for Genetics and Life Sciences, “Sirius” University
Author for correspondence.
Email: plotnikova.m.u.1996@gmail.com
Russia, 119991, Moscow; Russia, 354340, Krasnodarskiy kray, p. Sirius
A. D. Patrikeev
Vavilov Institute of General Genetics Russian Academy of Sciences
Email: plotnikova.m.u.1996@gmail.com
Russia, 119991, Moscow
A. Yu. Levchenko
Institute of Translational Biomedicine, Saint-Petersburg State University
Email: plotnikova.m.u.1996@gmail.com
Russia, 199034, Saint-Petersburg
O. Yu. Fedorenko
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: plotnikova.m.u.1996@gmail.com
Russia, 634014, Tomsk
T. V. Andreeva
Vavilov Institute of General Genetics Russian Academy of Sciences; Center for Genetics and Life Sciences, “Sirius” University; Lomonosov Moscow State University
Email: plotnikova.m.u.1996@gmail.com
Russia, 119991, Moscow; Russia, 354340, Krasnodarskiy kray, p. Sirius; Russia, 119991, Moscow
E. I. Rogaev
Vavilov Institute of General Genetics Russian Academy of Sciences; Center for Genetics and Life Sciences, “Sirius” University; Lomonosov Moscow State University
Email: plotnikova.m.u.1996@gmail.com
Russia, 119991, Moscow; Russia, 354340, Krasnodarskiy kray, p. Sirius; Russia, 119991, Moscow
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