Advances in Chemical PhysicsAdvances in Chemical PhysicsФизиология растений0015-33033034-624XThe Russian Academy of Sciences26945910.31857/S0015330324050037MNAFWVОБЗОРЫReview ArticleРекомбинантные моноклональные антитела, синтезируемые в растительных системах экспрессии: проблемы и перспективыРекомбинантные моноклональные антитела, синтезируемые в растительных системах экспрессии: проблемы и перспективыЗагорскаяА. А.
Russian Federation
zagorska@bionet.nsc.ruДейнекоЕ. В.
Russian Federation
zagorska@bionet.nsc.ruФедеральное государственное бюджетное научное учреждение “Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук”15092024715Генетическая инженерия растений – достижения и перспективы5205371111202411112024Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://journals.rcsi.science/0015-3303/article/view/269459

В последнее десятилетие широкое распространение получили моноклональные антитела (МКА) в качестве диагностических и терапевтических препаратов. Их основное преимущество заключается в высокой специфичности, низкой токсичности и, соответственно, более высокой безопасности при лечении инфекционных и онкологических заболеваний. Широкие возможности использования МКА привели к активной разработке технологий их производства. В обзоре описываются преимущества растительных систем для наработки МКА по сравнению с традиционными системами экспрессии. Особое внимание уделяется исследованиям, направленным на увеличение уровня экспрессии рекомбинантных МКА, приближение профиля гликозилирования к белкам человека, а также на отработку технологических особенностей, позволяющих добиться конкурентоспособности МКА растительного происхождения. Отдельный раздел посвящен успехам, достигнутым в этой области. В заключительной части рассмотрены перспективы исследований, связанные с получением МКА растительного происхождения с улучшенными свойствами.

В последнее десятилетие широкое распространение получили моноклональные антитела (МКА) в качестве диагностических и терапевтических препаратов. Их основное преимущество заключается в высокой специфичности, низкой токсичности и, соответственно, более высокой безопасности при лечении инфекционных и онкологических заболеваний. Широкие возможности использования МКА привели к активной разработке технологий их производства. В обзоре описываются преимущества растительных систем для наработки МКА по сравнению с традиционными системами экспрессии. Особое внимание уделяется исследованиям, направленным на увеличение уровня экспрессии рекомбинантных МКА, приближение профиля гликозилирования к белкам человека, а также на отработку технологических особенностей, позволяющих добиться конкурентоспособности МКА растительного происхождения. Отдельный раздел посвящен успехам, достигнутым в этой области. В заключительной части рассмотрены перспективы исследований, связанные с получением МКА растительного происхождения с улучшенными свойствами.

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