Effect of External Factors on the Structure of Ultrathin Fibers of Poly(3-Hydroxybutyrate) and Dipyridamole

Abstract

Fibrous materials based on poly(3-hydroxybutyrate) containing the drug dipyridamole were investigated. The structural–dynamic characteristics of the materials were studied by scanning electron microscopy, differential scanning calorimetry, and ESR spectroscopy. The effect of a series of aggressive factors (temperature, water, ozone) on the structure of the poly(3-hydroxybutyrate) fibers with dipyridamole was investigated for the first time. It was established that the enthalpy of fusion of the fibers increases when dipyridamole is added. Complex relationships between the specific enthalpy of fusion of the crystallites and the molecular mobility of the radical are observed during the action of aggressive factors on the fibrous materials.