Metformin inhibits development of colon malignant tumors induced by 1,2-dimethylhydrazine in rats

V. M. Patsanovskii; A. D. Nozdrachev; V. N. Anisimov; V. V. Bekusova

doi:10.1134/S0012496616030017

Metformin inhibits development of colon malignant tumors induced by 1,2-dimethylhydrazine in rats

Авторы: Patsanovskii V.M.¹, Nozdrachev A.D.², Anisimov V.N.³, Bekusova V.V.²
Учреждения:
1. Pavlov Institute of Physiology
2. St. Petersburg State University
3. Petrov Research Institute of Oncology
Выпуск: Том 468, № 1 (2016)
Страницы: 97-100
Раздел: Physiology
URL: https://journals.rcsi.science/0012-4966/article/view/153700
DOI: https://doi.org/10.1134/S0012496616030017
ID: 153700

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Аннотация

It has been shown that metformin dose-dependently inhibits the development of colon tumors induced by 1,2-dimethylhydrazine (DMH) in rats. The metformin effect manifested itself as a decrease in the amount and average size of tumors, increased degree of their differentiation, and reduction of invasion depth, which was more pronounced in the group of animals that received metformin at a dose of 100 mg/kg of body weight as compared with rats treated with metformin at a dose of 300 mg/kg.