Email this article Roles of leptin and ghrelin in the regulation of the phenotype and cytokine production by NK cells from peripheral blood
- Authors: Shirshev S.V.1, Nekrasova I.V.1, Orlova E.G.1, Gorbunova O.L.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- Issue: Vol 470, No 1 (2016)
- Pages: 249-252
- Section: Cell Biology
- URL: https://journals.rcsi.science/0012-4966/article/view/153877
- DOI: https://doi.org/10.1134/S0012496616050136
- ID: 153877
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Abstract
Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II–III of pregnancy increase the number of CD56bright NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-β1, IL-17А, or IFN-γ by NK cells, and they inhibit the production of IL-10. Leptin decreses the IL-4 production by NKp46+ cells, but the presence of ghrelin abrogates this effect.
About the authors
S. V. Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Author for correspondence.
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
I. V. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
E. G. Orlova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
O. L. Gorbunova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
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