Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia
- 作者: Korovaitseva G.1, Gabaeva M.1, Yunilainen O.1, Golimbet V.1
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隶属关系:
- Research Сenter of Mental Health
- 期: 卷 168, 编号 1 (2019)
- 页面: 84-86
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242241
- DOI: https://doi.org/10.1007/s10517-019-04653-3
- ID: 242241
如何引用文章
详细
The role of the VNTR polymorphism of the AS3MT gene in determining the clinical features of schizophrenia and schizophrenic spectrum disorders was studied. The analysis included 670 individuals. We found no differences in PANSS scores for positive, negative, and common psychopathological symptoms between the carriers of different genotypes. The interaction of the studied polymorphism and obstetrical complications as an environmental factor was found. The genotype-environment interactions were identified for one of the characteristics reflecting the severity of schizophrenia: the level of negative symptoms. Women with the V2/V2 genotype, who have obstetrical complications, showed significantly higher negative symptoms scores, which was associated with a poor prognosis of the disease.
作者简介
G. Korovaitseva
Research Сenter of Mental Health
编辑信件的主要联系方式.
Email: korovaitseva@mail.ru
俄罗斯联邦, Moscow
M. Gabaeva
Research Сenter of Mental Health
Email: korovaitseva@mail.ru
俄罗斯联邦, Moscow
O. Yunilainen
Research Сenter of Mental Health
Email: korovaitseva@mail.ru
俄罗斯联邦, Moscow
V. Golimbet
Research Сenter of Mental Health
Email: korovaitseva@mail.ru
俄罗斯联邦, Moscow