Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
- 作者: Kolik L.1, Nadorova A.1, Antipova T.1, Kruglov S.1, Kudrin V.1, Durnev A.1
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隶属关系:
- V. V. Zakusov Research Institute of Pharmacology
- 期: 卷 167, 编号 5 (2019)
- 页面: 641-644
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241980
- DOI: https://doi.org/10.1007/s10517-019-04588-9
- ID: 241980
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详细
The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal. In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05). These results indicate positive effects of the tuftsin analogue on age-related memory disturbances associated with chronic alcohol intoxication and confirm the involvement of the neurotrophin mechanism related to BDNF production into the effect of Selank.
作者简介
L. Kolik
V. V. Zakusov Research Institute of Pharmacology
编辑信件的主要联系方式.
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow
A. Nadorova
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow
T. Antipova
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow
S. Kruglov
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow
V. Kudrin
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow
A. Durnev
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow