Reaction of the Palatine Tonsillar Immunocompetent Cells to Irrigation of Crypts by Suspension of Silica Nanoparticles under Conditions of Chronic Tonsillitis
- 作者: Zhuravskii S.1,2, Shakhnazarov A.1, Yukina G.1, Samusenko I.3, Kryzhanovskaya E.1
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隶属关系:
- I. P. Pavlov St. Petersburg First State Medical University, Ministry of Health of Russia
- Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of Russia
- A. M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of the Russian Federation for Civil Defence, Emergencies, and Elimination of Consequences of Natural Disasters
- 期: 卷 167, 编号 3 (2019)
- 页面: 396-399
- 栏目: Biotechnologies
- URL: https://journals.rcsi.science/0007-4888/article/view/241748
- DOI: https://doi.org/10.1007/s10517-019-04535-8
- ID: 241748
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详细
We studied the response of neutrophils, macrophages, and mast cells to local application of silica nanoparticles (10-20 nm). Histological examination of tonsillar postoperative material from 6 patients aged 24-44 years with recurrent tonsillitis was carried out. Irrigation of the tonsillar lacunae was carried out over 5 days before bilateral tonsillectomy: on the right by Polysorb MP suspension (1 g/liter), on the left by saline. The contact of nanoparticles with the mucosa led to a decrease in the number of cells expressing myeloperoxidase (p=0.02) and an increase in the count of CD68+ cells (p=0.04); the count of mast cells remained unchanged. Local use of medical adsorbent based on silica nanoparticles induced changes in cells due to their resorption by the tissue. Positive chemotaxis of CD68+ macrophages revealed in the tonsillar lymphoid tissue attested to stimulation of non-specific immunity and inductive phase of specific immunity. The authors hypothesized that internalization of medical nanoparticles by resident phagocytes of the mucosa could support targeted biodistribution of drugs in the palatine tonsils.
作者简介
S. Zhuravskii
I. P. Pavlov St. Petersburg First State Medical University, Ministry of Health of Russia; Institute of Experimental Medicine, V. A. Almazov National Medical Research Center, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: s.jour@mail.ru
俄罗斯联邦, St. Petersburg; St. Petersburg
A. Shakhnazarov
I. P. Pavlov St. Petersburg First State Medical University, Ministry of Health of Russia
Email: s.jour@mail.ru
俄罗斯联邦, St. Petersburg
G. Yukina
I. P. Pavlov St. Petersburg First State Medical University, Ministry of Health of Russia
Email: s.jour@mail.ru
俄罗斯联邦, St. Petersburg
I. Samusenko
A. M. Nikiforov All-Russian Center of Emergency and Radiation Medicine, Ministry of the Russian Federation for Civil Defence, Emergencies, and Elimination of Consequences of Natural Disasters
Email: s.jour@mail.ru
俄罗斯联邦, St. Petersburg
E. Kryzhanovskaya
I. P. Pavlov St. Petersburg First State Medical University, Ministry of Health of Russia
Email: s.jour@mail.ru
俄罗斯联邦, St. Petersburg