Kinetics of Serum Cytokine Profile in Mice after Injection of Supernatants of Group A Streptococci Culture
- 作者: Danilova Т.1, Danilina G.1, Аdzhieva А.1, Minko A.1
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隶属关系:
- Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- 期: 卷 167, 编号 3 (2019)
- 页面: 367-370
- 栏目: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241702
- DOI: https://doi.org/10.1007/s10517-019-04528-7
- ID: 241702
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详细
We analyzed cytokine profile in the sera of CBA mice in 1, 5, and 24 h after intraperitoneal injection of supernatants of broth cultures of group A Streptococcus types 1M and 3M and Dochez NY5 type 10M strain. The increase of the cytokine content was observed in response to supernatants of all three types, but the highest values were recorded after injection of supernatant of strain Dochez-NY5. The level of IL-2 increased most drastically (by 51 times) and the level of IL-5 increased by 8.9 times in comparison with the control. The level of IL-2 also increased after injection of supernatants of type 1M and type 3M, but to a lesser extent (by 5 and 2.3 times, respectively). The content of proinflammatory cytokines IL-1β, TNFα, and IFNγ in mouse sera increased to a lesser extent than IL-2 after administration of all three supernatants.
作者简介
Т. Danilova
Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: dansen@inbox.ru
俄罗斯联邦, Moscow
G. Danilina
Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: dansen@inbox.ru
俄罗斯联邦, Moscow
А. Аdzhieva
Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: dansen@inbox.ru
俄罗斯联邦, Moscow
A. Minko
Laboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: dansen@inbox.ru
俄罗斯联邦, Moscow
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