Role of Carbon Monoxide in the Mechanisms of Action of Extracellular ATP on Contractile Activity of Vascular Smooth Muscle Cells
- 作者: Smagliy L.1, Yartseva Y.1, Rydchenko V.1, Birulina Y.1, Gusakova S.1, Kovalev I.1, Petrova I.1, Nosarev A.1
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隶属关系:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 167, 编号 3 (2019)
- 页面: 363-366
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241700
- DOI: https://doi.org/10.1007/s10517-019-04527-8
- ID: 241700
如何引用文章
详细
We studied the role of carbon monoxide (CO) in the effect of P2X and P2Y receptor agonist ATP on the tone of rat aorta segments with intact endothelium. ATP (1-1000 μM) and P2X receptor agonist α,β-MeATP (100 μM) relaxed segments precontracted with phenylephrine (10 μM), while UTP (100-1000 μM) increased the amplitude of phenylephrine-induced contraction. The relaxing effect of ATP was enhanced by CORM II (100 μM), NO synthase inhibitor L-NAME, and guanylate cyclase inhibitor ODQ and attenuated by ZnPP IX (100 μM). The constrictive effect of UTP was weakened by CORM II (100 μM), but was not changed by ZnPP IX (100 μM). ZnPP IX (100 μM) weakened the relaxation response to α,β-MeATP. Thus, ATP involves the CO-dependent signaling cascade through P2X receptors.
作者简介
L. Smagliy
Siberian State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: lud.smagly@yandex.ru
俄罗斯联邦, Tomsk
Yu. Yartseva
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: lud.smagly@yandex.ru
俄罗斯联邦, Tomsk
V. Rydchenko
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: lud.smagly@yandex.ru
俄罗斯联邦, Tomsk
Yu. Birulina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: lud.smagly@yandex.ru
俄罗斯联邦, Tomsk
S. Gusakova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: lud.smagly@yandex.ru
俄罗斯联邦, Tomsk
I. Kovalev
Email: lud.smagly@yandex.ru
I. Petrova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: lud.smagly@yandex.ru
俄罗斯联邦, Tomsk
A. Nosarev
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: lud.smagly@yandex.ru
俄罗斯联邦, Tomsk
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