Magnetic Resonance Imaging in Assessment of Cardiac Remodeling in Rats with Experimental Arterial Hypertension
- 作者: Agafonova I.1, Kotel’nikov V.2, Geltser B.2
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隶属关系:
- G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences
- Far-Eastern Federal University
- 期: 卷 167, 编号 3 (2019)
- 页面: 320-324
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241675
- DOI: https://doi.org/10.1007/s10517-019-04518-9
- ID: 241675
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详细
Magnetic resonance imaging was employed to examine the morphofunctional status of myocardium in Wistar rats with multifactor cardiovasorenal model of arterial hypertension. In 3 months after the onset of experiment, the rats demonstrated a pronounced hypertrophy in left ventricular myocardium mostly due to thickening of the posterior and lateral walls against the background of relatively stable thickness of ventricular septum. The left ventricular endsystolic volume markedly increased in parallel with moderate increase of the end-diastolic volume. The standard calculated indices were used for precise assessment of the type of remodeling of individual myocardial structures. The study showed that multifactor arterial hypertension model was characterized by domination of hypertrophic mode of the left ventricular remodeling, whereas the concentric variant was observed more rarely by 2.5 times. The greatest alterations were observed in the posterior and lateral walls of the left ventricle, which could result from the hemodynamic effects of hypervolemic arterial hypertension.
作者简介
I. Agafonova
G. B. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far-East Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: agafonova@piboc.dvo.ru
俄罗斯联邦, Vladivostok
V. Kotel’nikov
Far-Eastern Federal University
Email: agafonova@piboc.dvo.ru
俄罗斯联邦, Vladivostok
B. Geltser
Far-Eastern Federal University
Email: agafonova@piboc.dvo.ru
俄罗斯联邦, Vladivostok