Effect of Linagliptin on the Ratio of Apoptosis Regulators in the Model of Non-Alcoholic Fatty Liver Disease in db/db Mice
- 作者: Michurina S.1, Cherepanova M.1, Ishchenko I.1, Arkhipov S.1, Klimontov V.1, Zav’yalov E.2
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隶属关系:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
- Federal Research Center Institute for Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- 期: 卷 167, 编号 2 (2019)
- 页面: 210-214
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241589
- DOI: https://doi.org/10.1007/s10517-019-04493-1
- ID: 241589
如何引用文章
详细
We studied the effects of dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin on the expression of apoptosis regulator proteins Bcl-2 and Bad in the liver of db/db mice with genetically determined obesity and type 2 diabetes mellitus. The mice received daily linagliptin or saline (placebo) by gavage from week 10 to week 18 of life. In the liver of non-treated mice, the area positively stained for Bad was greater than the area of Bcl-2 expression, which created the conditions for apoptosis activation in liver at this age. Administration of linagliptin decreased Bad stained area and increased Bcl-2 stained area in the liver cells. At the same time, Bad stained area remained larger in treated mice than the area of Bcl-2 expression area, which attested to partial normalization of pro- and antiapoptotic protein balance.
作者简介
S. Michurina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
编辑信件的主要联系方式.
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
M. Cherepanova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
I. Ishchenko
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
S. Arkhipov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
V. Klimontov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
E. Zav’yalov
Federal Research Center Institute for Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
俄罗斯联邦, Novosibirsk
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