Interaction of NK Cells, Trophoblast, and Endothelial Cells during Angiogenesis
- 作者: Belyakova K.1, Stepanova O.1, Sheveleva A.1, Mikhailova V.1, Sokolov D.1, Sel’kov S.1
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隶属关系:
- D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
- 期: 卷 167, 编号 1 (2019)
- 页面: 169-176
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/241551
- DOI: https://doi.org/10.1007/s10517-019-04484-2
- ID: 241551
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详细
We studied changes in angiogenesis during contact interaction of natural killer cells and endothelial cells in the presence of secretory products of trophoblast cells activated by various cytokines. Activated trophoblast regulates angiogenesis by producing soluble factors that affect endothelial cells either directly or indirectly through activation of proangiogenic activity of natural killer cells. A stimulating effect of the trophoblast supernatants activated by IL-1β and an inhibitory effect of trophoblast supernatants activated by IL-6 and TGFβ for the formation of tube-like structures by endothelial cells were revealed. During contact culturing, natural killer cells increased the length of tube-like structures formed by endothelial cells. The trophoblast activated by IL-1β affects angiogenesis both directly through the production of proangiogenic factors and indirectly through activation of the proangiogenic potential of natural killer cells. Trophoblast activated by IFNγ affects angiogenesis only by stimulating the proangiogenic potential of natural killer cells. Under conditions of contact interaction of natural killer cells and endothelial cells, soluble factors of trophoblast activated by IL-6 or TGFβ attenuated the angiogenesis-stimulating effect of natural killer cells.
作者简介
K. Belyakova
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
O. Stepanova
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
A. Sheveleva
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
V. Mikhailova
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
D. Sokolov
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
编辑信件的主要联系方式.
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg
S. Sel’kov
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: falcojugger@yandex.ru
俄罗斯联邦, St. Petersburg