Comparative Assessment of the Effectiveness of Noncompetitive NMDA Receptor Antagonists Amantadine and Hemantane in Morphine Withdrawal Syndrome Model
- 作者: Kolik L.1, Konstantinopolsky M.1
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隶属关系:
- V. V. Zakusov Research Institute of Pharmacology
- 期: 卷 166, 编号 6 (2019)
- 页面: 739-743
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241324
- DOI: https://doi.org/10.1007/s10517-019-04430-2
- ID: 241324
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详细
Activities of noncompetitive NMDA receptor antagonists (aminoadamantane derivatives) were assessed in random-bred rats with modeled morphine withdrawal syndrome. A single intraperitoneal injection of hemantane (10 or 20 mg/kg) significantly and dose-dependently moderated some behavioral symptoms (teeth-chattering, ptosis, and vocalization) and reduced total score of morphine withdrawal syndrome. In morphine-abstinent rats, hemantane partially prevented the decrease in the thresholds of tactile sensitivity, but had no effect on locomotor activity and body weight loss. Under conditions of morphine withdrawal, intraperitoneal injection of amantadine (10 or 20 mg/kg) decreased motor activity and promoted body weight loss in parallel with the development of mechanical allodynia, but had no effect on the total withdrawal score. Comparison of aminoadamantane derivatives by behavioral and physiological parameters demonstrated the advantage of hemantane during morphine abstinence indicating the need of its study as a promising anti-addiction remedy.
作者简介
L. Kolik
V. V. Zakusov Research Institute of Pharmacology
编辑信件的主要联系方式.
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow
M. Konstantinopolsky
V. V. Zakusov Research Institute of Pharmacology
Email: lgkolik@mail.ru
俄罗斯联邦, Moscow