On the Mechanism of the Cardioprotective Action of σ1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole)
- 作者: Kryzhanovskii S.1, Kozhevnikova L.2, Tsorin I.1, Sukhanova I.2, Ionova E.1, Stolyaruk V.1, Vititnova M.1, Miroshkina I.1, Seredenin S.1
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隶属关系:
- V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
- Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences
- 期: 卷 165, 编号 5 (2018)
- 页面: 660-664
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240643
- DOI: https://doi.org/10.1007/s10517-018-4236-1
- ID: 240643
如何引用文章
详细
Original translational rat model of chronic heart failure provoked by experimental anterior transmural myocardium infarction was employed to examine the preventive action of anxiolytic Afobazole (15 mg/kg/day administered intraperitoneally during the first 15 days after coronary occlusion) on the development of the heart failure assessed in 3 months after infarction. Afobazole prevented the development of pathologic remodeling of the myocardium, maintained its inotropic function, and decreased the plasma level of brain natriuretic peptide known as a biochemical marker of chronic heart failure. In the myocardium, Afobazole down-regulated overexpression of the genes induced in chronic heart failure and assessed by corresponding RNA levels, which code angiotensin (AT1A-R), vasopressin (V1A-R), and glucocorticoid (GR) receptors as well as Epac2 protein. The revealed biochemical changes are consistent with the data on cardioprotective action of Afobazole.
作者简介
S. Kryzhanovskii
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
L. Kozhevnikova
Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
I. Tsorin
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
I. Sukhanova
Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
E. Ionova
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
V. Stolyaruk
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
M. Vititnova
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
I. Miroshkina
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
S. Seredenin
V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow