Effects of Exposure of Animals to Oxygen Atmosphere at Low Pressure on Lipid Peroxidation and Antioxidant Defense
- 作者: Ryabchenko N.1, Dzikovskaya L.1, Izmest’eva O.1, Zhavoronkov L.1
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隶属关系:
- A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
- 期: 卷 165, 编号 5 (2018)
- 页面: 640-643
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240622
- DOI: https://doi.org/10.1007/s10517-018-4231-6
- ID: 240622
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详细
Relatively short-term (2.5 or 5 h) exposure of Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) resulted in an increase in LPO level and reduction of antioxidant activity in the blood serum. An increase in malondialdehyde concentration 1 day after termination of the exposure was followed by a decrease in the inhibiting activity of free radical oxidation of liposomal phospholipids induced by Fe(II) ions (100 μm). Malondialdehyde concentration increased by 1.29 times already after 2.5-h exposure and did not changed when the duration of the exposure to oxygen atmosphere was prolonged to 5 h. These data confirm the necessity of using substances potentiating antioxidant defense of the body during exposure to normobaric oxygenation.
作者简介
N. Ryabchenko
A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: olgaizmestieva@mail.ru
俄罗斯联邦, Obninsk
L. Dzikovskaya
A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: olgaizmestieva@mail.ru
俄罗斯联邦, Obninsk
O. Izmest’eva
A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: olgaizmestieva@mail.ru
俄罗斯联邦, Obninsk
L. Zhavoronkov
A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: olgaizmestieva@mail.ru
俄罗斯联邦, Obninsk